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EC number: 444-000-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
EL10 and EL50 (21 d) >100 mg/L (nominal) (Daphnia magna, OECD 211)
NOELR (21 d) ≥100 mg/L (nominal) (Daphnia magna, OECD 211)
No effects up to the limit of the water solubility of the substance (read-across)
Key value for chemical safety assessment
Additional information
In accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the structurally similar analogue substance dipentaerythritol hexa esters of pentanoic, heptanoic and trimethylhexanoic acid (CAS 67762-52-1) was conducted to fulfil the data requirements according to Annex VII - IX of dipentaerythritol ester of nC5/iC9 acids (CAS 647028-25-9) in regard to long-term toxicity to invertebrates.
This read-across is justified in detail in the overall summary (IUCLID section 6.1) and within the analogue justification in IUCLID section 13. The source substances consist of the same alcohol component (dipentaerythritol) and similar fatty acid chain lengths as the target substance (C5-9iso for the target substance compared to C5-9 for the source substances, respectively).
The study used for read across was performed according to OECD 211 under GLP conditions (Ablitt, 2015). Daphnia magna were exposed to water accommodated fractions (WAFs) with a nominal loading rates of 1, 10, and 100 mg/L in a semi-static test for 21 d. The test substance loading rates were analysed using HPLC-MS-analysis. Chemical analysis of the fresh and aged test preparations showed measured test concentrations ranging from <LOQ to 0.0269 mg/L and <LOQ to 0.0240 mg/L, respectively. No mortality or adverse effects on mobility and reproduction were observed. Therefore, for reproduction the EL10 and EL50 were determined to be > 100 mg/L (nominal). The NOELR and the LOELR were determined to be ≥100 mg/L and >100 mg/L, respectively
Based on the result from the structurally related read-across substance dipentaerythritol hexa esters of pentanoic, heptanoic and trimethylhexanoic acid (CAS 67762-52-1) it can be concluded that dipentaerythritol ester of nC5/iC9 acids (CAS 647028-25-9) will not exhibit long-term toxic effects to Daphnia up to the limit of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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