Benzyldimethylamine

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1989-03-14 - 1989-06-15

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Qualifier:

according to guideline

Guideline:

other: "Bioaccumulation test of chemical substance in fish and shellfish", order of the prime minister, the minister of health and welfare, the minister of international trade and industry No 1, Japan, 1974

Principles of method if other than guideline:

This guideline corresponds to OECD Guideline 305C (Bioaccumulation: Test for the degree of bioconcentration in Fish), 1981

GLP compliance:

not specified

Radiolabelling:

no

Details on sampling:

- Sampling intervals/frequency for test organisms: every two weeks, n=2, control fish analysis: before the initiation and the termination of exposure, n=2
- Sampling intervals/frequency for test medium samples: twice a week, n=1

Vehicle:

not specified

Details on preparation of test solutions, spiked fish food or sediment:

It is necessary to prepare a solution of the test substance 100 times higher concentrated than that in the aquarium. If the test substance is not soluble enough in water, suitable solubilisers were used. More detailled information is not available for the substance tested.

Test organisms (species):

Cyprinus carpio

Details on test organisms:

Supplier: Sugishima fish farm, Japan
Weight: about 30g, Length: about 10 cm, Lipid content: 2-6 % (at the initiation of exposure)

Route of exposure:

aqueous

Test type:

flow-through

Water / sediment media type:

natural water: freshwater

Total exposure / uptake duration:

6 wk

Test temperature:

25+-2°C

Dissolved oxygen:

6-8 mg/L

Details on test conditions:

Test tank: 100L glass tank
Number of fish: 15-20 fish/Level
Renewal rate of test solutions: flow rate 200-800 mL/min

Nominal and measured concentrations:

Considering of the result of preliminary test for 48-hr LC50 and analytically detecting limit of the test substance, test concentrations were decided.
1st concentration: 500 µg/L
2nd concentration: 50 µg/L

Lipid content:

> 2 - < 6 %

Time point:

start of exposure

Type:

BCF

Value:

2.1 - 6.4 dimensionless

Basis:

whole body w.w.

Calculation basis:

steady state

Remarks on result:

other: Conc.in environment / dose:500 µg/L

Type:

BCF

Value:

6.2 - 22 dimensionless

Basis:

whole body w.w.

Calculation basis:

steady state

Remarks on result:

other: Conc.in environment / dose:50 µg/L

Details on results:

Preliminary test:
species: Rice fish (Oryzais latipes)
The LC50 is 59.3 mg/L at 48 hours.

Calculation of bioconcentration factor

BCF = concentration of test substance in fish/concentration of test substance in water

Executive summary:

Benzyldimethylamine determined to be non or not highly bioaccumulative. The BCF at the first concentration of 500 µg/L is 2.1 to 6.4 , and at the second concentration of 50 µg/L the BCF is <6.2 to 22. The study was conducted according to "Bioaccumulation test of chemical cubstance in fish and shellfish", order of the prime minister, the minister of health and welfare, the minister of international trade and industry No 1, Japan, 1974.

(MITI-Online, MITI-Buch, 1992)

Description of key information

Benzyldimethylamine was determined to be non or not highly bioaccumulative (MITI-Online, MITI-Buch, 1992).

Key value for chemical safety assessment

BCF (aquatic species):

22 L/kg ww

Additional information

Benzyldimethylamine was determined to be non or not highly bioaccumulative. The BCF at a concentration of 500 µg/L is 2.1 to 6.4, and at a concentration of 50 µg/L the BCF is <6.2 to 22. The study was conducted according to "Bioaccumulation test of chemical substance in fish and shellfish", order of the prime minister, the minister of health and welfare, the minister of international trade and industry No 1, Japan, 1974 (MITI-Online, MITI-Buch, 1992).