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EC number: 239-183-9 | CAS number: 15123-80-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 Nov - 01 Dec 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study. (The LLNA is not recommended for certain metals.)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Version / remarks:
- (adopted July 2010)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
- Version / remarks:
- (EC Directive 2004/73/EC)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- GYEMSZI, National Institute for Quality- and Organizational Development in Healthcare and Medicines, National Institute of Pharmacy, Budapest, Hungary
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Dodecaaluminium trimolybdenum dodecaoxide
- EC Number:
- 239-183-9
- EC Name:
- Dodecaaluminium trimolybdenum dodecaoxide
- Cas Number:
- 15123-80-5
- Molecular formula:
- Al2Mo3O12
- IUPAC Name:
- dialuminium(3+) tris(dioxomolybdenumbis(olate))
- Details on test material:
- - Name of test material (as cited in study report): Aluminium molybdate
- Physical state/appearance: solid, white
- Analytical purity: > 99%
- Lot/batch No.: GRA 2011-10-13-01
- Storage: room temperature
- Expiry date: Nov 2018
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- other: CBA/Ca
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: TOXI-COOP ZRT., H-1103, Budapest, Cserkesz u.90.
- Age at study initiation: 8 - 11 weeks
- Weight at study initiation: 17.9 - 22.5 g
- Housing: groups of 4, in type II polypropylene/polycarbonate cages
- Diet: Ssniff SM R/M-Z+H complete diet for rats and mice (Ssniff Spezialdiäten GmbH, D-59494 Soest, Germany); ad libitum
- Water: tap water; ad libitum
- Acclimation period: 7 and 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12/12
Study design: in vivo (LLNA)
- Vehicle:
- dimethylformamide
- Concentration:
- 10%, 25%, and 50%
- No. of animals per dose:
- 4
- Details on study design:
- RANGE FINDING TESTS:
The preliminary irritation/toxicity screen was performed with 50% and 25% (w/v) as suspension in DMF.
No mortality, no obvious signs of systemic toxicty and no significant signs of irritation were observed. Thus, test item concentration of 50% was selected as the highest test concentration in the main test.
MAIN STUDY
ANIMAL ASSIGNMENT AND TREATMENT
- Name of test method: Local Lymph Node Assay
- Criteria used to consider a positive response: If the stimulation index (SI) value is increased at least 3-fold, the test substance is considered a skin sensitizer.
TREATMENT PREPARATION AND ADMINISTRATION:
Each mouse was topically treated with 25 µL of the appropriate formulations of the test item, the positive control substance and the vehicle using a pipette, on the dorsal surface of each ear. Each animal was dosed once a day on 3 consecutive days. There was no treatment on days 4, 5, and 6.
On day 6, the animals were intravenously injected via the tail vein with 250 µL of sterile PBS containing 20 µCi of ³H-methyl-thymmidine. Once injected, the mice were left for 5 hours (± 30 min).
Then, the mice were anaesthetized and sacrificed. The draining auricular lymph nodes were excised, removed and pooled per group.
A single cell suspension of lymph node cells was prepared.
For the measurement of incorporated radioactivity the vials were loaded into a beta-scintillation counter and ³HTdR incorporation was measured for up to 10 min per sample, expressed as the amount of radioactive disintegration per minute (DPM).
The stimulation index is calculated: SI = DPN treated/DPN neg. control (DPN = DPM divided by the number of pooled lymph nodes)
A stimulation index of >= 3 is an indication of a positive result.
VEHICLE
- Choice for vehicle: The following substances were tested as vehicle: Acetone: Olive oil 4:1 mixture (v/v) (AOO), N,N-Dimethylformamide (DMF), DMSO, and purified water. Based on the solubility, DMF was chosen as vehicle for the test substance and AOO as vehicle for positive control. - Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: - negative control (DMF): 1.0 - 50%: 0.9 - 25%: 0.4 - 10%: 0.4 - positive control: 5.5 - negative control (AOO): 1.0
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: - negative control (DMF): 7319 - 50%: 6377.5 - 25%: 3269.5 - 10%: 2948.5 - positive control: 40665.5 - negative control (AOO): 7390.5
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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