Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 252-038-4 | CAS number: 34452-51-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05-June-2000 - 19-July-2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Potassium mercaptoacetate
- EC Number:
- 252-038-4
- EC Name:
- Potassium mercaptoacetate
- Cas Number:
- 34452-51-2
- Molecular formula:
- C2H4O2S.K
- IUPAC Name:
- potassium sulfanylacetate
- Reference substance name:
- KTG
- IUPAC Name:
- KTG
- Test material form:
- solid - liquid: suspension
- Details on test material:
- Test substance: aqueous solution of potassium thioglycolate
Batch number: B00S5611
Content of active ingredient (potassium thioglycolate): 42.5 % (w/w)
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Male and female Sprague Dawley rats CD (Crl: CD (SD) IGS BR)
- Supplier: Charles River (UK) Ltd, Margate, Kent, UK
- Weight: 221-229 g (M), 202-232 g (F)
- Age: 12 weeks
- Acclimatization: at least 5 days
- Housing: groups of 3 by sex in solid-floor polypropylene cages
- Diet: ad libitum except fasting (Rat and Mouse Expanded Diet N°1, Special Diets Services Limited, Witham, Essex, UK)
- Water: drinking water ad libitum
- Fasting: overnight before dosing and 3-4 hours after dosing
CONDITIONS:
- Temperature: 19-25 °C
- Relative Humidity: 30-70 %
- Air changes: approx. 15/hour
- Dark-Light cycle (hours): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 200, 500 and 2000 mg/kg potassium thioglycolate as 42.5% solution.
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- All animals were dosed once only by gavage. The animals were observed for death or overt signs of toxicity 1/2, 1, 2 and 4 hours after dosing and subsequently twice daily for up to 14 days. Individual body weights were recorded prior to dosing and 7 and 14 days after treatment or at death. At the end of the observation period, animals were subjected to macroscopic examination. No tissue was retained.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 200 - <= 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals treated with 2000 mg/kg, one animal treated with 500 mg/kg and one animal treated with 200 mg/kg were found dead during the day of dosing. The two remaining animals treated with 500 mg/kg were found dead one day after dosing.
- Clinical signs:
- other: Hunched posture was commonly noted at dose levels of 2000 mg/kg, 500 mg/kg and in females treated with 200 mg/kg with lethargy also commonly noted at 2000 mg/kg and ataxia also commonly noted at 500 mg/kg. lncidents of decreased respiratory rate and labou
- Gross pathology:
- Abnormalities noted at necropsy of animals that died during the study were haemorrhagic lungs, dark liver, dark kidneys, epithelial sloughing of thegastric mucosa and haemorrhage of the bladder. No abnormalities were noted at necropsy of animals that were killed at the end of the study.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The acute oral median lethal dose LD50 of potassium thioglycolate 43% solution was estimated to be in the range of 200-500 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.