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EC number: 251-646-7 | CAS number: 33703-08-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 02 - 16 Aug 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study with structurally similar source substance
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
See explainations in the endpoint study summary and the analogue justification document attached in chapter 12. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- 865 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 550-1000 mg/kg
- Duration:
- 7 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 550 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
Reference
Description of key information
Key value for chemical safety assessment
Additional information
Since no study assessing the toxicity of DINA to soil macroarthropods is available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to the structurally very similar Bis(2-ethylhexyl) adipate (CAS 103-23-1, DEHA) was conducted. The read across is justified due to the similarity of structure and functional groups and accordingly similar physico-chemical properties which result in similar environmental behavior and fate (see table below).
Substance |
Diisononyl adipate |
Bis(2-ethylhexyl) adipate |
CAS number |
33703-08-1 |
103-23-1 |
Structure |
see attachment |
see attachment |
Molecular formula |
C24H46O4 |
C22H42O4 |
Molecular weight |
398.63 g/mole |
370.58 g/mole |
PC parameter |
|
|
Water solubility |
RA to 103-23-1 |
0.0032 mg/L (EU A.6) |
Partition coefficient |
9.54 (OECD 117) |
8.94 (OECD 117) |
Vapour pressure |
0.00000002 hPa at 20 °C (calculation) |
0.0000003 hPa at 20 °C (calculation) |
Environmental fate |
|
|
Biodegradability |
> 90% in 28 days (OECD 301F) |
>90% in 28 days (OECD 301F) |
Adsorption [log KOC] |
5.15 (calculation) |
4.56 (calculation) |
Hydrolysis |
not relevant |
|
Ecotoxicology |
|
|
Short-term toxicity to fish [96h-LC50] |
No toxicity within the limit of water solubility |
No toxicity within the limit of water solubility |
Long-term toxicity to aquatic invertebrates [NOEC] |
- |
- |
Short-term toxicity to aquatic invertebrates [48h-EC50] |
No toxicity within the limit of water solubility |
No toxicity within the limit of water solubility |
Long-term toxicity to aquatic invertebrates [21d-NOEC] |
RA from 103 -23 -1 |
No toxicity within the limit of water solubility |
Short-term toxicity to algae [72h-EC50] |
No toxicity within the limit of water solubility |
No toxicity within the limit of water solubility |
Long-term toxicity to algae [72h-NOEC/EC10] |
No toxicity within the limit of water solubility |
No toxicity within the limit of water solubility |
Toxicity to microorganisms [NOEC] |
The inhibition of the degradation activity of activated sludge is not anticipated when DINA is introduced in appropriate low concentrations. |
The inhibition of the degradation activity of activated sludge is not anticipated when DEHA is introduced in appropriate low concentrations. |
The short-term toxicity test with DEHA was performed according to EU method C.8 using Eisenia foetida as test organisms (Huels 1996). Different nominal concentrations between 100 and 1000 mg/kg d.w. were tested. Mortality was recorded after 7 and 14 days exposure time. Whereas no earthworm died in the control and test concentrations up to 500 mg/kg, 17 animals (out of 40) died in the 1000 mg/kg treatment. Thus, the 14d-LC50 is determined to be 865 mg/kg d.w. based on nominal concentrations.
Based on the mentioned structural similarities between the source and the target substance resulting in a similar efate and ecotoxicological profile this efferct value can also considered to be true for Diisononyl adipate (CAS 33703-08-1) and thus adequately covers this endpoint for the hazard assessment of DINA.
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