Registration Dossier
Registration Dossier
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EC number: 252-899-6 | CAS number: 36177-92-1
Endpoint summary
Administrative data
Description of key information
Additional information
The toxicity of N-butyl-2,2,6,6-tetramethylpiperidin-4-amine (N-butyl TAD) has been assessed for the three standard aquatic trophic levels. For fish, a toxicity test with Danio rerio has been conducted according to EU method C.1 and revealed an effect level >100 mg/L. This result is supported by another study with the orfe, which showed a LC50 of 206 mg/L. In an acute toxicity test with daphnia magna according to EU method 84/449/EC C.2, the EC50 has been determined to 20 mg/L. A second study with Dapnia magna demonstrated a LC50 of 28.1 mg/L, supporting the results of the key study. The toxicity on algae has been determined with the green algae Scenedesmus subspicatus with analytic detection of the test substance. An effect concentration EC50 of 10.1 mg/L and a NOEC of 3.7 mg/L has been determined based on the biomass after 72 h. Based on these data, the algae is the most sensitive organism towards the exposure with N-butyl-TAD.
Long-term studies on invertebrates and fish are not available for N-butyl TAD. The long-term tests with the test substance are not required as the risk assessment reveals no unacceptable effects of the test substance on aquatic organisms (risk characterization ratios <1).
The effect of the test substance to microorganism has been shown to be >100 mg/L after 3 h in a bacteria inhibition test according to guideline 87/302/EEC in compliance to GLP.
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