Registration Dossier
Registration Dossier
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EC number: 201-855-4 | CAS number: 88-74-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Toxicity and Skin Corrosion Data for Some Organic and Inorganic Compounds and Aqueous Solutions.
- Author:
- Vernot E.H. et al.
- Year:
- 1 977
- Bibliographic source:
- Toxicol. Appl. Pharmacol. 42: 417-423
Materials and methods
- Principles of method if other than guideline:
- The method used for skin absorption toxicity was essentially that of Smyth et at. (1962), except that three female albino New Zealand rabbits were used per dose and the doses were kept in place by 8-ply gauze patches under a latex rubber film.
Smyth et al. (1962). Range-finding toxicity data: List VI. Amer. Ind. Hyg. Ass. J. 23: 95-107. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-nitroaniline
- EC Number:
- 201-855-4
- EC Name:
- 2-nitroaniline
- Cas Number:
- 88-74-4
- Molecular formula:
- C6H6N2O2
- IUPAC Name:
- 2-nitroaniline
- Details on test material:
- - Name of test material (as cited in study report): o-Nitroaniline
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 3-4 kg
- Diet (ad libitum): Purina Rabbit Chow
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of exposure:
- 24 hrs
- Doses:
- 20000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 20 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0/3 animals died during the study.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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