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EC number: 232-218-9 | CAS number: 7790-69-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Based on the results of the acute oral toxicity study of lithium nitrate a LD50 of 1317 (male), 1519 (female) and 1426 (Combined) mg/kg bw was derived. Under the conditions of the acute inhalation study, the 4-h LC50 for lithium nitrate solution is greater than 5.93 mg/L (discriminating concentration). Based on the findings in the acute dermal toxicity study, a single dermal administration of lithium nitrate in water did not induce any test item related adverse effects and a LD50 of >2000 mg/kg bw (discriminating dose) could be derived.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-03-26 to 1999-05-06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- February 24th 1987
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Version / remarks:
- January 1993
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Version / remarks:
- August 1998
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories
- Age at study initiation: young adults
- Weight at study initiation: 207-275 g
- Fasting period before study: yes
- Housing: individually housed in stainless steel, suspended cages
- Diet (e.g. ad libitum): Purina Rodent Chow 5001 (pellets), ad libitum
- Water (e.g. ad libitum): Fresh tap water, ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 65-71
- Humidity (%): 50-61
- Photoperiod (hrs dark / hrs light): 12/12 - Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- - Amount of vehicle (if gavage):
Dosage group 2000 mg/kg, males: 1.8 - 1.9 mL
Dosage group 2000 mg/kg females: 1.7 - 1.8 mL
Dosage group 1500 mg/kg males: 1.3 - 1.4 mL
Dosage group 1500 mg/kg females: 1.3 mL
Dosage group 1000 mg/kg males: 0.94 - 1.1 mL
Dosage group 1000 mg/kg females: 0.83 - 0.90 mL - Doses:
- 1000, 1500, 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 animals/dose/sex
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 0.5, 1, 2, 3, 4, 6 h following dosing and daily thereafter for 14 days
- Necropsy of survivors performed: yes , any animal not surviving to termination were also necropsied.
- clinical signs: 0.5, 1, 2, 3, 4, 6 h following dosing and daily thereafter for 14 days
- body weight: was recorded on days 0, 7 and 14 - Statistics:
- The oral LD50 value and 95 % confidence limits for separate and combined sexes were calculated using a modified Logit-Linear Regression Program written by Jim Gibbons, Texas Instruments Calculator Products Division.
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 317 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 993 - <= 1 640
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 519 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 179 - <= 1 859
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 426 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 242 - <= 1 609
- Mortality:
- All deaths occurred within 5 days of dosing. Data is summarized below.
- Clinical signs:
- other: All deaths occurred within 5 days after dosing. The most significant clinical signs were twitching, rolling over in cage, recumbency, loss of muscle control, squinting eyes and tremors. All signs subsided by study day 6.
- Gross pathology:
- Red liquid was found in the stomach of one decedent and red liquid was found in the intestines of another decedent. Animals sacrificed at study termination on day 14 were found to be normal at necropsy.
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Based on the results of the acute oral toxicity study of lithium nitrate a LD50 of 1317 (male), 1519 (female) and 1426 (Combined) mg/kg bw was derived.
- Executive summary:
Groups of five male and female Sprague-Dawley rats were orally administered lithium nitrate by a 25 % (w/v) preparation in tap water. Observations for toxicity were conducted 0.5, 1, 2, 3, 4, and 6 hours post-dosing, and daily thereafter for fourteen days. Body weights were recorded weekly and prior to necropsy. Gross necropsies were performed on all animals. All deaths occurred within 5 days of dosing. The most significant clinical signs were twitching, rolling over in cage, recumbency, loss of muscle control, squinting eyes and tremors. All signs subsided by study day 6; surviving rats remained healthy and gained weight until study termination. Red liquid was found in the stomach of one and in the intestine of another decedent. Animals sacrificed at study termination on day 14 were found to be normal at necropsy. The LD50 values determined were 1317 mg/kg in male rats, 1519 mg/kg in female rats, and 1426 mg/kg in combined sexes. (FMC, 1999)
Reference
The summarized mortality data:
Male | Female | Combined | |||
Dosage Level (mg/kg bw) | No. dead / No. dosed | Dosage Level (mg/kg bw) | No. dead / No. dosed | Dosage Level (mg/kg bw) | No. dead / No. dosed |
2000 | 5/5 | 2000 | 5/5 | 2000 | 10/10 |
1500 | 4/5 | 1500 | 2/5 | 1500 | 6/10 |
1000 | 0/5 | 1000 | 0/5 | 1000 | 0/10 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 426 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-12-07 to 2000-02-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- May 12th 1981
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- Version / remarks:
- December 29th 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1300 (Acute inhalation toxicity)
- Version / remarks:
- August 1998
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories
- Age at study initiation: young adults
- Weight at study initiation: 247-268 g
- Fasting period before study: no
- Housing: individually housed in stainless steel, suspended cages
- Diet (e.g. ad libitum): Purina Rodent Chow 5001 (pellets), ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 67-68
- Humidity (%): 52-61
- Photoperiod (hrs dark / hrs light): 12/12 - Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- clean air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: a dynamically-operated, nose-only inhalation exposure chamber with 11 litres volume
- Method of holding animals in test chamber: housed in polycarbonate nose-only tubes during the exposure
- Method of particle size determination: The aerodynamic particle size distribution was determined by gravimetric analysis of the amount of test material collected on the impactor stages.
- Temperature, humidity, pressure in air chamber: Chamber, room air temperature and relative humidity were monitored continuously during the exposure with FMC wet/dry bulb hygrometers. Measurements were recorded at 30-minute intervals. The mean temperature and relative humidity in the chamber were 69 °F and 74 %, respectively. The mean temperature and relative humidity in the chamber room were 64 °F and 50 %, respectively.
TEST ATMOSPHERE
- Brief description of analytical method used: Chamber air samples were taken on German® Type A/E 37 mm glass fiber filters held in cassettes at approximately 40-minute intervals during the exposure to determine the airborne concentration of test material. The concentration was calculated by dividing the filter weight gain by the sample volume. The filters were then desiccated overnight and reweighed for determination of dry concentration. The dry concentration was then divided by the fraction of solids (0.32) to yield the formulation concentration.
- Samples taken from breathing zone: Yes, the samples were taken from the center of the chamber directly above the animal tube portals.
TEST ATMOSPHERE
- Particle size distribution: Chamber air samples were taken twice during the exposure to determine the aerodynamic particle size distribution of airborne test material. The samples were drawn through a Sierra® Model 218 cascade impactor at 2.82 liters per minute. The filters were then desiccated overnight and reweighed for determination of dry filter weight.
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): The mass median aerodynamic diameter (MMAD), geometric standard deviation (GSD) and the percent of aerosol less than or equal to 1,10, and 15 microns in size were determined by logarithmic-probability plotting. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- formulation concentration: 5.93 mg/L
- No. of animals per sex per dose:
- 5 animals/sex/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations at fifteen-minute intervals during the first hour of exposure, hourly for the remainder of the exposure, upon removal from the chamber, at one hour post-exposure and daily thereafter for fourteen days
- Necropsy of survivors performed: yes
- body weight: once a week - Statistics:
- Particle size distributions were determined by log-probability plotting of the data and subsequent determination of the mass median aerodynamic diameter, geometric standard deviation and other particle size parameters from the data plots. The LC50 and 95 % confidence limits were determined by a suitable logit or probit analysis.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.93 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- There were no deaths during the study.
- Clinical signs:
- other: Treatment-related clinical signs noted during the study included dyspnea and lacrimation. All animals were normal on study day 1 and remained normal through study termination. Another sign noted that was attributed to animal exposure tube confinement was
- Body weight:
- At termination, all animals exhibited increases in body weight over their day 0 values.
- Gross pathology:
- There were no gross internal lesions observed in any animal at necropsy.
- Other findings:
- The results of the particle size distribution indicated the test material was respirable in size to the rat.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this study, the four-hour LC50 for lithium nitrate solution was greater than 5.93 mg/L.
- Executive summary:
A group of five male and five female Sprague-Dawley rats was exposed to a respirable aerosol of lithium nitrate solution (30 %). Animals were exposed for 4 hours at a mean, formulation concentration of 5.93 mg/L in a dynamically-operated, nose-only inhalation exposure chamber. Gravimetric airborne test material samples were taken frequently during the exposure. Particle size samples were taken twice during the exposure. Observations for toxicity and mortality were performed frequently during the exposure, upon removal of the rats from the chamber, at one hour post-exposure and daily thereafter for 14 days. Individual body weights were recorded immediately prior to exposure on day 0 and on days 7 and 14. On day 14, all animals were sacrificed and gross necropsy examinations were performed.
All animals survived to study termination. Treatment-related clinical signs noted during the study included dyspnea and lacrimation. All animals were normal from day 1 through study termination. All animals gained weight during the study. There were no gross internal lesions observed in any animal at necropsy.
Under the conditions of this study, the four-hour LC50 for lithium nitrate solution is greater than 5.93 mg/L. (FMC, 1999/2000)
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating conc.
- Value:
- 5 930 mg/m³ air
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-04-06 to 1999-04-20
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- February 24th 1987
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Version / remarks:
- January 1993
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- Version / remarks:
- August 1998
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories
- Age at study initiation: young adults
- Weight at study initiation: 247-274 g
- Fasting period before study: no
- Housing: Individually, in suspended stainless steel cages, wire bottom
- Diet (e.g. ad libitum): Purina Laboratory Rodent Chow 5001 (pellets), ad libitum
- Water (e.g. ad libitum): Domestic water supply (untreated with additional chlorine or HCl), ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 65-67
- Humidity (%): 53-61
- Photoperiod (hrs dark / hrs light): 12/12 - Type of coverage:
- occlusive
- Vehicle:
- other: moistened with 0.5 mL of tap water.
- Details on dermal exposure:
- TEST SITE
- Area of exposure: scapular to the pelvic region
- Type of wrap if used: hypoallergenic tape
REMOVAL OF TEST SUBSTANCE
- Washing: rinsed with water
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied: depending on the body weight 0.52-0.55 g (males); 0.49-0.54 g (females)
- Concentration: 2000 mg/kg bw
- For solids, paste formed: yes
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 animals/sex/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observation for mortality 0.5, 1, 2, 3, 4, 6 hours after dosing and daily thereafter for 14 days
- Necropsy of survivors performed: yes
- clinical signs: observation were done 0.5, 1, 2, 3, 4, 6 hours after dosing and daily thereafter for 14 days
- body weight: was recorded on the day of dosing and again on days 7, 14
- local irritation: was recorded on days 1, 3, 7, 14 - Statistics:
- The dermal LD50 value and corresponding 95 % confidence limits for separate and combined sexes (if possible) were calculated using a modified Logit-Linear Regression Program written by Jim Gibbons, Texas Instruments Calculator Products Division.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths were noted.
- Clinical signs:
- other: Clinical signs noted during the study included abnormal posture, exaggerated hindlimb flexion, staggered gait, abdominogenital staining, abdominal gripping, no feces, chromodacryorrhea, decreased locomotion, diarrhea and unthriftiness. All but one rat rec
- Gross pathology:
- No gross internal lesions were observed in any animal during necropsy.
- Other findings:
- Local irritation: Irritation noted included erythema of the test sites in all rats on day 1. Desquamation, erythema and eschar were noted in some animals on days 3, 7 and 14.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the findings of this study, a single dermal administration of lithium nitrate did not induce mortality as well as test item related adverse effects. A LD50 of >2000 mg/kg bw was determined.
- Executive summary:
Lithium nitrate was topically applied to five Sprague-Dawley rats per sex at a dosage level of 2000 mg/kg bw. The test material was in contact with the skin under an occlusive wrap for 24 hours. Observations for toxicity were conducted 0.5, 1, 2, 3, 4, and 6 hours post-dosing, and daily thereafter for fourteen days. Dermal irritation was recorded on days 1, 3, 7 and 14. Body weights were recorded weekly. Gross necropsies were performed on all animals.
No deaths were noted. Clinical signs noted during the study included abnormal posture, exaggerated hindlimb flexion, staggered gait, abdominogenital staining, abdominal gripping, no feces, chromodacryorrhea, decreased locomotion, diarrhea and unthriftiness. All but one rat recovered by study day 2; one male displayed signs until study day 8. All rats gained weight by day 14 of the study. Irritation noted included erythema of the test sites in all rats on day 1. Desquamation, erythema and eschar were noted in some animals on days 3, 7 and 14. No gross lesions were revealed during necropsy. The LD50 determined was greater than 2000 mg/kg bw in both male and female rats. (FMC, 1999)
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
Additional information
Acute oral toxicity
Groups of five male and female Sprague-Dawley rats were orally administered lithium nitrate by a 25 % (w/v) preparation in tap water. Observations for toxicity were conducted 0.5, 1, 2, 3, 4, and 6 hours post-dosing, and daily thereafter for fourteen days. Body weights were recorded weekly and prior to necropsy. Gross necropsies were performed on all animals. The LD50 values in mg/kg bw and the corresponding 95 % confidence limits are as follows: Male: 1317 (993-1640); Female: 1519 (1179-1859); Combined: 1426 (1242-1609). All deaths occurred within 5 days of dosing. The most significant clinical signs were twitching, rolling over in cage, recumbency, loss of muscle control, squinting eyes and tremors. All signs subsided by study day 6; surviving rats remained healthy and gained weight until study termination. Red liquid was found in the stomach of one and in the intestines of another decedent. Animals sacrificed at study termination on day 14 were found to be normal at necropsy. The LD50 is 1317 mg/kg in male rats, 1519 mg/kg in female rats, and 1426 mg/kg in combined sexes. (FMC, 1999)
Acute inhalation toxicity
A group of five male and five female Sprague-Dawley rats was exposed to a respirable aerosol of lithium nitrate solution. Animals were exposed for 4 hours at a mean formulation concentration of 5.93 mg/L in a dynamically-operated, nose-only inhalation exposure chamber. Gravimetric airborne test material samples were taken frequently during the exposure. Particle size samples were taken twice during the exposure. Observations for toxicity and mortality were performed frequently during the exposure, upon removal of the rats from the chamber, at one hour post-exposure and daily thereafter for 14 days. Individual body weights were recorded immediately prior to exposure on day 0 and on days 7 and 14. On day 14, all animals were sacrificed and gross necropsy examinations were performed.
All animals survived to study termination. Treatment-related clinical signs noted during the study included dyspnea and lacrimation. All animals were normal from day 1 through study termination. All animals gained weight during the study. There were no gross internal lesions observed in any animal at necropsy.
Under the conditions of this study, the 4-h LC50 for lithium nitrate solution is greater than 5.93 mg/L.(FMC, 2000)
Acute dermal toxicity
Lithium nitrate was topically applied to five Sprague-Dawley rats per sex at a dosage level of 2000 mg/kg bw. The test material was in contact with the skin under an occlusive wrap for 24 hours. Observations for toxicity were conducted 0.5, 1, 2, 3, 4, and 6 hours post-dosing, and daily thereafter for fourteen days. Dermal irritation was recorded on days 1, 3, 7 and 14. Body weights were recorded weekly. Gross necropsies were performed on all animals.
No deaths were noted. Clinical signs noted during the study included abnormal posture, exaggerated hindlimb flexion, staggered gait, abdominogenital staining, abdominal gripping, no feces, chromodacryorrhea, decreased locomotion, diarrhea and unthriftiness. All but one rat recovered by study day 2; one male displayed signs until study day 8. All rats gained weight by day 14 of the study. Irritation noted included erythema of the test sites in all rats on day 1. Desquamation, erythema and eschar were noted in some animals on days 3, 7 and 14. No gross lesions were revealed during necropsy.
The LD50 is greater than 2000 mg/kg bw for both male and female rats when topically applied. (FMC, 1999)
Justification for selection of acute toxicity – oral endpoint
GLP and guideline compliant study.
Justification for selection of acute toxicity – inhalation endpoint
GLP and guideline compliant study.
Justification for selection of acute toxicity – dermal endpoint
GLP and guideline compliant study.
Justification for classification or non-classification
Based on the results of the acute oral toxicity study lithium nitrate is classified and labelled as Xn (Harmful), R22 (Harmful if swallowed) according to Directive 67/548/EEC (DSD) and acute toxicity cat. IV (H302: Harmful if swallowed) according to Regulation (EC) No 1272/2008 (CLP).
Based on the results of the acute dermal and acute inhalation toxicity study, the test substance is not subjected to classification and labelling according to Directive 67/548/EEC (DSD) and Regulation (EC) No 1272/2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.