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EC number: 231-831-9 | CAS number: 7758-05-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Dose doc no. : P255
- Author:
- RSC Publishing
- Year:
- 2 011
- Bibliographic source:
- Dictionary of Substances and their effects (DOSE); J. Pharmacol. Exp. Ther. 1957, 120, 171.
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Potassium iodate
- EC Number:
- 231-831-9
- EC Name:
- Potassium iodate
- Cas Number:
- 7758-05-6
- Molecular formula:
- HIO3.K
- IUPAC Name:
- potassium iodate
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 140 mg kg-1
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 140 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: other details not available
Applicant's summary and conclusion
- Conclusions:
- LD50 mouse (i.p) : 140 mg/kg bw
- Executive summary:
Abstract
Single-dose, acute toxicity experiments, carried out with white Swiss mice, using potassium and sodium iodates and the corresponding iodides, led to the following conclusions:
Administered in sufficient quantities, the iodates cause intoxication and death. In some instances, death is attributed to renal damage with retention of non-protein nitrogen. Hemolytic effects are evidenced by hemoglobinuria and, histologically, by hemoglobin casts and hemosiderin deposits in the kidneys.
Fatty visceral changes, non-specific in nature, appear within 24 hours after ingestion of iodates or iodides. Similar changes occur in fasted animals.
Oral administration of iodates, at levels of 140 to 500 mgm./kgm., often increase the pH of the gastric contents. This is frequently accompanie by degenerative changes in the parietal cells. The damage is transient, as evidenced by restoration to normal in histological appearance of the gastric mucosa and in the pH values after 24 hours. Intraperitoneal and intravenous injections of iodates have little effect on the gastric pH.
The toxicity of potassium iodate varies greatly with the route of administration; the oral LD50for mice fasted on sawdust overnight is six times that of the intraperitoneal LD50. Potassium iodate and sodium iodate have nearly identical oral toxicities and similar intraperitoneal toxicities; the oral toxicity of the potassium compound is nearly the same for heavy and light mice and for both sexes, and is not increased in weanling animals.
Similarly, the relative toxicities of iodates and iodides depend on route of administration and on previous treatment of the mice.
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