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EC number: 204-269-7 | CAS number: 118-69-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Remarks:
- combined repeated dose and reproduction / developmental screening
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2,6-dichlorotoluene
- EC Number:
- 204-269-7
- EC Name:
- 2,6-dichlorotoluene
- Cas Number:
- 118-69-4
- Molecular formula:
- C7H6Cl2
- IUPAC Name:
- 1,3-dichloro-2-methylbenzene
- Details on test material:
- - Analytical purity: 99.2%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Duration of treatment / exposure:
- For 2 weeks prior to mating and 2 weeks of mating. Further for 2 weeks after mating in males and throughout pregnancy up till day 3 post partum in females.
- Frequency of treatment:
- Daily
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
30mg/kg/day
Basis:
other: in corn oil
- Remarks:
- Doses / Concentrations:
100mg/kg/day
Basis:
other: in corn oil
- Remarks:
- Doses / Concentrations:
300mg/kg/day
Basis:
other: in corn oil
- Remarks:
- Doses / Concentrations:
1000mg/kg/day
Basis:
other: in corn oil
- No. of animals per sex per dose:
- Males, 13; females, 13
- Control animals:
- yes, concurrent vehicle
Results and discussion
Effect levels
open allclose all
- Dose descriptor:
- NOEL
- Effect level:
- 30 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- NOEL
- Effect level:
- 100 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- female
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
1. Males: Decrease in locomotor activity was observed in one animal in the 300 mg/kg group, as well as decrease in locomotor activity (9 animals) and adoption of a prone position (2 animals) in the 1000 mg/kg group. Body weight gain was suppressed in the 300 and 1000 mg/kg groups. Autopsy following treatment for 42 days demonstrated increases in the relative kidney weights in the 300 and 1000 mg/kg groups and the relative liver weights in the 1000 mg/kg group. As histopathological findings, increase in eosinophilic bodies in the kidneys was observed in the groups receiving 100 mg/kg or more, and centrilobular hypertrophy and ground glass appearance of the hepatocytes were observed in those with 300 mg/kg and more. Decrease in the concentration of glucose was determined in the 300 and 1000 mg/kg groups. No effects of 2,6-dichlorotoluene were observed on food consumption and hematology.
2. Females: Decrease in locomotor activity (all animals tested), adoption of a prone position (10 animals) and incomplete eyelid opening (6 animals) were observed in the 1000 mg/kg group. Food consumption was decreased as well as suppression of body weight gain in the 1000 mg/kg group. At autopsy on postpartum day 4, increases in the relative kidney weight and relative liver weight were found in the 1000 mg/kg group. As histopathological findings, vacuolar and fatty degeneration in the proximal kidney tubules and centrilobular hypertrophy of the hepatocytes were observed in the 300 and 1000 mg/kg groups. In addition, decreases in the relative thymus weight and atrophy of the thymus were observed in the 300 mg/kg and more groups. No effects of 2,6-dichlorotoluene were observed on urinalysis.
Applicant's summary and conclusion
- Conclusions:
- NOELs for repeated dose toxicity of 2,6-dichlorotoluene are considered to be 30 mg/kg/day in males and 100 mg/kg/day in females.
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