Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-532-3 | CAS number: 107-92-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
In two primary skin irritation tests according or similar to OECD test guideline 404, butyric acid was demonstrated to be corrosive on basis of EU regulations.
In a primary eye irritation test comparable to OECD test guideline 405, butyric acid was demonstrated to be corrosive on basis of EU regulations.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation
Two valid studies are available to assess the skin irritating potential of butyric acid.
Hoechst AG, Rupprich 1983 (key study)
In a valid GLP OECD 404 study, 3 rabbits were exposed dermally to a single dose of 0.5 mL of undiluted butyric acid for a period of one hour .Butyric acid was corrosive as evidenced by skin lesions, severe hardening and discoloring which persisted until the end of the 14 day observation period (Hoechst AG, 1983).
Celanese, Ebbens 1972
In a primary skin irritation test (DOT test), six adult albino New Zealand rabbits were dermally exposed to 0.5 mL of butyric acid for 1 hour. Irritation was scored at 1, 24 and 72 hours by a grading system similar to Draize/OECD TG 404. The animals showed deep chemical burns over the entire site at all observation time points. Observation was terminated after 72 hours (Celanese, 1972).
Based on present EU regulations, butyric acid is corrosive as evidenced by deep skin lesions at all observation time points, which were not reversible.
Eye irritation
One valid study is available to assess the eye irritating potential of butyric acid.
BASF AG 1978
In a primary eye irritation test, 50 µL of butyric acid (purity 99%) was instilled into the conjunctival sac of one eye each of two male Vienna White rabbits. Animals then were observed for 8 days. The original irritation readings were converted to the Draize score at a later date. Readings were taken 24 h, 48 h, and 8 d after application of test substance.
The treated eyes showed severe opacity and chemosis, which persisted until the end of the observation period (8 d) with no tendency to subside.
In this study, butyric acid was tested to be corrosive to the eye (irreversible effects on the eye - Category 1) based on the irreversibility of the effects observed.
This pre-guideline study bears some deviations from present test guidelines (amount of test substance, observation period, time of irritation score readings). Nevertheless, the data are assessed to be sufficiently valid to represent the eye damaging potential of butyric acid, as the correct amount of test substance would result in even more pronounced effects. Using available results conforms to the tiered testing and evaluation strategy for eye irritation/corrosion and further testing can be avoided.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Due to the irreversible corrosive effects of butyric acid to the skin and the eye of rabbits, it has to be classified as skin corrosive Category 1 and as causing irreversible effects on the eye (Category 1).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)