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EC number: 221-499-3 | CAS number: 3121-61-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions. No details on analytical purity of the test substance. Occlusive test conditions and limited details on test animals and environmental conditions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- no details on analytical purity of the test substance; occlusive test conditions; limited details on test animals and environmental conditions
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-methoxyethyl acrylate
- EC Number:
- 221-499-3
- EC Name:
- 2-methoxyethyl acrylate
- Cas Number:
- 3121-61-7
- Molecular formula:
- C6H10O3
- IUPAC Name:
- 2-methoxyethyl acrylate
- Details on test material:
- - Name of test material (as cited in study report): Methyl Cellosolve Acrylate, 2-Methoxyethoxy Propenoate
- Analytical purity: no data
- Other: Sample No. 31-126; Reg. No. 511-01-4353, received from Union Carbide Corporation, Chemicals and Plastics Division, South Charleston, WV
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Housing: animals were housed in immobilization devices in inhalation chambers with heads protruding into the study room to prevent inhalation of the substance. After treatment, animals were returned to their standard housing.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: clipped trunk of the rabbit under a cotton pad
- Type of wrap if used: the entire trunk was then wrapped in an impervious Vinylite covering.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): residual test substance was washed.
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied: 0.125, 0.25 and 0.5 mL/kg - Duration of exposure:
- 24 h
- Doses:
- 0.125 mL/kg bw corresponding to 126.25 mg/kg bw
0.25 mL/kg bw corresponding to 252.5 mg/kg bw
0.5 mL/kg bw corresponding to 505 mg/kg bw
Based on a test substance density of 1.01 g/cm³. - No. of animals per sex per dose:
- 4
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- The LD50 value was calculated via the probit method.
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 252.5 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- ca. 171.7 - ca. 373.7
- Remarks on result:
- other: based on a density of 1.01 g/cm³
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 0.25 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- 0.17 - 0.37
- Mortality:
- 126.25 mg/kg bw: no animal died
252.5 mg/kg bw: 2 animals died
505.0 mg/kg bw: all animals died - Clinical signs:
- other: No clinical signs of toxicity were observed in the animals at any dose level.
- Gross pathology:
- At gross pathology, mottled liver was found.
- Other findings:
- - Other observations:
No skin irritation was observed in the surviving animals treated with 252.5 and 505 mg/kg bw.
Any other information on results incl. tables
Table 1. Acute dermal toxicity
Dose |
Toxicological results* |
Duration of clinical signs |
Time of death |
Mortality (%) |
Males |
||||
126.25 |
0/0/4 |
--- |
--- |
0 |
252.5 |
2/0/4 |
--- |
Day 1 |
50 |
505 |
4/0/4 |
--- |
Day 2 |
100 |
LD50 = 252.5 mg/kg bw |
second number = number of animals with clinical signs
third number = number of animals used
Table 2. Body weight changes
Dose [mg/kg bw] |
Weight Change* |
126.25 |
+++- |
252.5 |
+- |
505 |
N/A |
*all surviving animals;
+ = animals with weight gain
- = animals with weight loss
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- CLP: Acute dermal 3, H311
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