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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 913-888-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: expert statement
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Based on the current knowledge the statement has been written.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
- Objective of study:
- absorption
- Principles of method if other than guideline:
- no guideline as it is an expert statement
- GLP compliance:
- no
Test material
- Reference substance name:
- Monoammonium phosphate (MAP)
- IUPAC Name:
- Monoammonium phosphate (MAP)
- Reference substance name:
- Ammonium dihydrogenorthophosphate
- EC Number:
- 231-764-5
- EC Name:
- Ammonium dihydrogenorthophosphate
- Cas Number:
- 7722-76-1
- Molecular formula:
- H3N.H3O4P
- IUPAC Name:
- ammonium dihydrogen phosphate
- Reference substance name:
- DIammonium phosphate (DAP)
- IUPAC Name:
- DIammonium phosphate (DAP)
- Reference substance name:
- Diammonium hydrogenorthophosphate
- EC Number:
- 231-987-8
- EC Name:
- Diammonium hydrogenorthophosphate
- Cas Number:
- 7783-28-0
- Molecular formula:
- H9N2O4P
- IUPAC Name:
- diammonium hydrogen phosphate
- Reference substance name:
- triammonium dihydrogen phosphate hydrogen phosphate
- EC Number:
- 913-888-8
- Molecular formula:
- H3N.H3O4P H9N2O4P
- IUPAC Name:
- triammonium dihydrogen phosphate hydrogen phosphate
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
- Radiolabelling:
- no
Results and discussion
Main ADME results
- Type:
- absorption
- Results:
- Based on low MW and high water solubility: 100% oral absorption is expected. For dermal exposure 10% absorption is taken, due to the high water solubility and ionisation of the two components.
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Based on low MW and high water solubility oral absorption is expected. Therefore, 100% absorption is taken for oral exposure.
since the vapour pressure of the reaction mass is assimilated to the vapour pressure of water, inhalation exposure to the liquid form of the
reaction mass is not expected.
For dermal exposure 10% absorption is taken, due to the high water solubility and ionisation of the two components.
Any other information on results incl. tables
In general, a compound needs to be dissolved before it can be taken up from the gastro-intestinal tract after oral administration. MAP and DAP will be dissociated in its ions in water. (Di)hydrogenphosphate is in equilibrium with phosphate. The transport of phosphate from the lumen is an active, energy-dependent process. In general, about two thirds of the ingested phosphate is absorbed from the gastrointestinal tract in adults. After ingestion, ammonium ions can be absorbed by diffusion of the unionized ammonia or by active transport of ammonium ion. After intestinal absorption, ammonium ions are converted to urea by the liver, and subsequently excreted in urine. The relatively small molecular weights (below 200) and the high water solubility (>10 g/L) indicate that uptake of MAP and DAP can also take place through aqueous pores. It is therefore likely that MAP and DAP will be absorbed from the gastro-intestinal tract. Oral absorption of the liquid form of the reaction mass of MAP and DAP is set at 100%.
Once absorbed, distribution of Ammonium dihydrogenorthophosphate and Diammonium hydrogenorthophosphate throughout the body is expected based on their relatively low molecular weight, and no accumulation in the body is anticipated based on their hydrophilic character. Ammonium dihydrogenorthophosphate and Diammonium hydrogenorthophosphate have characteristics favourable for fast urinary excretion: low molecular weight (below 200), good water solubility, and ionization of the molecules at the pH of urine. Based on its hydrophilic character, extracellular concentration is also expected to be higher than intracellular concentration.The rate at which these highly water-soluble molecules distribute may be limited by the rate at which they cross cell membranes and access of these substances to the central nervous system (CNS) or testes is likely to be restricted by the blood-brain and blood-testes barriers.
Since the vapour pressure of the liquid form of the reaction mass of Ammonium dihydrogenorthophosphate and Diammonium hydrogenorthophosphate is low (assimilated to the vapour pressure of water), inhalation exposure to the liquid form of the reaction mass is not expected.
Ammonium dihydrogenorthophosphate and Diammonium hydrogenorthophosphate ionize as soon as they dissolve and having water solubility above 10 g/L. Moreover, these substances may be too hydrophilic to cross the lipid rich environment of the stratum corneum. Therefore, 10% dermal absorption of the reaction mass is proposed.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.