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Diss Factsheets
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EC number: 203-047-7 | CAS number: 102-69-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable well documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 969
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Penetration of rabbit skin is estimated by a technique closely akin to the one-day cuff method of Draize and associate. No information is on test animals and their environmental conditions as well as health state after the treatment.
- GLP compliance:
- no
- Remarks:
- the study was conducted prior adoption of GLP
- Test type:
- other: penetration on rabbit skin
- Limit test:
- no
Test material
- Reference substance name:
- Tripropylamine
- EC Number:
- 203-047-7
- EC Name:
- Tripropylamine
- Cas Number:
- 102-69-2
- Molecular formula:
- C9H21N
- IUPAC Name:
- tripropylamine
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Tripropylamine
- Substance type: organic
- Physical state: liquid
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.0-3.5 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back
- % coverage: entire trunk
- Type of wrap if used: imperious plastic film
The animals were immobilized during the exposure.
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): no data; Dosages greater than 20 mL/kg could not be retained in contact with the skin. - Duration of exposure:
- 24 hours
- Doses:
- No data
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: no data - Statistics:
- Based upon mortalities during a 14-day observation period, the most probable LD50 value and its fiducial range are estimated by the method of Thompson using the Tables of Weil. The figures' in parentheses show limits of ± 1.96 standard deviations while the absence of parentheses indicates that no range is calculable because no dosage resulted in fractional mortality.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 430 mg/kg bw
- Based on:
- test mat.
- Remarks:
- 0.57 mL/kg bw
- Remarks on result:
- other: (0.26-1.23), the dose is calculated based on density of 0.7557 g/cm³
- Mortality:
- No data
- Clinical signs:
- other: other: No data
- Gross pathology:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information GHS Criteria used for interpretation of results: EU
- Conclusions:
- LD50 of 0.57 mL/kg bw (corresponding to 430 mg/kg bw) was reported for tripropylamine. According to Regulation (EC) No 1272/2008, tripropylamine should be classified in Cat 3 as acute toxic substance by dermal route (H301 Toxic in contact with skin).
- Executive summary:
Tripropylamine was tested in a range-finding toxicity study in New Zealand rabbits (Smyth et al., 1969). Penetration of rabbit skin is estimated by a technique closely akin to the one-day cuff method of Draize and associates using groups of four male albino New Zealand rabbits weighing 2.5 to 3.5 kg. The fur is removed from the entire trunk by clipping, and the dose is retained beneath an impervious plastic film. Dosages greater than 20 ml/kg cannot be retained in contact with the skin. The animals are immobilized during the 24-hour contact period, after which the film is removed and the rabbits are caged for the subsequent 14-day observation period. Based upon mortalities during 14 -day observation period, the most probable LD50 value and its fiducial range are estimated by the method of Thompson using the Tables of Weil (references are cited in the publication). LD50 of 0.57 mL/kg bw (range 0.26 - 1.23) was reported for tripropylamine. The range shows limit of± 1.96 standard deviation. Based on the density of 0.7557 g/cm³ (Lechte, 2010), 0.57 mL/kg bw corresponds to 430 mg/kg bw.
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