Registration Dossier
Registration Dossier
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EC number: 212-751-3 | CAS number: 866-81-9
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
Based on the available data, DNELs for inhalation exposure were derived for workers.
The more critical DNEL for long-term inhalation, local effects is based on a LOAEC of 0.37 mg/m3determined in a subchronic inhalation study with rats and mice. Due to differences in exposure conditions between humans and experimental animals, the starting point needs to be modified since exposure duration as well as activity have to be taken into account (corrected LAEC) = 0.19 mg/m3). Using an assessment factor of 75 (2.5 (interspecies, local effects) x 5 (intraspecies) x 2 (subchronic to chronic) x 3 (extrapolation corrected LAEC to corrected NAEC), the resulting DNEL is 0.003 mg/m3.
A second DNEL for long-term inhalation, local effects is based on the LOAEC of a chronic inhalation study (LOAEC = 0.37 mg/m3) in rats and mice. Due to differences in exposure conditions between humans and experimental animals, the starting point needs to be modified since exposure duration as well as activity have to be taken into account (corrected LAEC) = 0.19 mg/m3). Using an assessment factor of 37.5 (2.5 (interspecies, local effects) x 5 (intraspecies) x 3 (extrapolation corrected LAEC to corrected NAEC), the resulting DNEL is 0.005 mg/m3.
However, since tricobalt dicitrate is only imported as already included into the matrix and the matrix particles are greater than 100 µm, a risk potential is not expected.
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
For the general population, DNELs do not need to be derived since Tricobalt dicitrate is used as an intermediate under strictly controlled conditions.
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