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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Adequacy of study:
other information
Rationale for reliability incl. deficiencies:
other: Literature A-L

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Oral Dehydroepiandrosterone for Adrenal Androgen Replacement: Pharmacokinetics and Peripheral Conversion to Androgens and Estrogens in Young Healthy Females after Dexamethasone Suppression
Author:
Arlt. W et. al.
Year:
1998
Bibliographic source:
Journal of Clinical Endocrinology and Metabolism, 83, 6, 1928-1934
Reference Type:
publication
Title:
Induction of Ovarian Granulosa Cell Tumors in SWXJ-9 Mice with Dehydroepiandrosterone
Author:
Beamer WG etl al.
Year:
1988
Bibliographic source:
Cancer Res, 48, 2788-2792
Reference Type:
publication
Title:
Historic reflection on steroids: Lederle and personal aspects
Author:
Bernstein S
Year:
1992
Bibliographic source:
Steroids 57, 392-402
Reference Type:
publication
Title:
Synthetic Spiro-neurosteroid Analogs Exerting Structure-Specific Neuroprotective Effects
Author:
Charalampopoulos I et. al.
Year:
2008
Bibliographic source:
Rev Clin Pharmacol Pharmacokin 22, 119-121
Reference Type:
publication
Title:
Oral dehydroepiandrosterone (DHEA) replacement therapy in women with Addison's disease
Author:
Gebre-Medhin G et. al.
Year:
2000
Bibliographic source:
Clinical Endocrinology, 52, 775-780
Reference Type:
publication
Title:
Virilization of the External Genitalia of the Female Rat Fetus by Dehydroepiandrosterone
Author:
Goldmann AS
Year:
1970
Bibliographic source:
Endocrinology, 87, 432-435
Reference Type:
publication
Title:
Effects of dehydroepiandrosterone on oleic acid accumulation in rat liver
Author:
Imai K et. al.
Year:
2003
Bibliographic source:
Biochemical Pharmacology, 65, 1583¿1591
Reference Type:
publication
Title:
Effects of Dehydroepiandrosterone (DHEA) on Ubiquinone and Catalase in the Livers of Male F-344 Rats
Author:
Khan SA
Year:
2005
Bibliographic source:
Biol. Pharm. Bull., 28(7), 1301¿1303
Reference Type:
publication
Title:
Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity
Author:
Kirkland D et. al.
Year:
2005
Bibliographic source:
Mutation Research 584, 1¿256
Reference Type:
publication
Title:
Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses?
Author:
Laube B et. al.
Year:
2002
Bibliographic source:
TRENDS in Pharmacological Sciences Vol.23 No.11, 519-527

Materials and methods

Results and discussion

Applicant's summary and conclusion