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EC number: 230-949-8 | CAS number: 7381-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04-08-1994
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Non GLP, Guideline study, sufficiently described, no CoA but some details like active ingredient content on the test substance in the report. Read-across is based upon a commonality of functional groups, constituents, breakdown products and metabolic pathways. A detailed justification is appended in Section 13.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- The test substance was weighed directly into the test vessels due to the limited solubility in water. The test solutions were before the start of the test for 30 minutes ultrasonically treated. 4 mg of Antifoam (SE-2) was added to each test vessel with test substance.
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- Dry weight in the test: 1600 mg/L
Origin of inoculum: Kommunale Abwasserreinigungsanlage Frankfurt/MSindlingen.
Pretreatment of sludge: according to the OECD guideline
Adaptation of the sludge: Not adapted - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Test temperature:
- 20 ± 2 °C
- pH:
- 7.2 ± 0.2
- Salinity:
- According to OECD 209 guideline
- Details on test conditions:
- Reference substance concentration: 5, 20 und 30 mg/L
Test substance concentrations: 62.5 to 1000 mg/L - Reference substance (positive control):
- yes
- Remarks:
- 3,5-Dichlorophenol
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 3 h
- Dose descriptor:
- other: EC20
- Effect conc.:
- 639 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Results with reference substance (positive control):
- Results for the reference substance and control were within the required limits.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test is not performed under GLP conditions but the results are considered reliable and valid. This result is therefore adequate for evaluating the hazard of coco fatty acids 2-sulfoethyl ester, sodium salt to sludge bacteria.
- Executive summary:
The median effect of coco fatty acids 2 -sulfoethyl ester, sodium salt the respiration of microorganisms present in activated sludge was observed to be >1000 mg/L.
Reference
Description of key information
The 3h-EC50 for activated sludge was > 687 mg/L and the 3h-EC20 was 439 mg/L in a respiration inhibition test with OECD Test Guideline 209 under GLP (concentration based on active ingredient).
Key value for chemical safety assessment
- EC50 for microorganisms:
- 687 mg/L
Additional information
There is no activated sludge, respiration inhibition test available for lauric acid 2-sulfoethyl ester, sodium salt (sodium lauroyl isethionate) CAS No 7381-01-3.
There is however a study on the source chemical Coco fatty acids 2 -sulfoethyl ester, sodium salt CAS no 61789 -32 -0, which is Klimisch rated 2 and was carried out according to the OECD guideline 209 , described in Reinhardt ,1994.
The toxicity to activated sludge was determined in a respiration inhibition test in accordance with OECD Test Guideline 209. The toxicity of the sodium salt of coco fatty acids 2 -sulfoethyl ester to activated sludge was determined at a contact time of 3 hours, using various concentrations of the test substance. The EC50 was reported as >1000 mg/L of test substance which corresponds with > 687 mg/L based on active ingredient concentration. The EC20 was 639 mg/L based on test material which corresponds with 439 mg/L base on active ingredient concentration. The substance is therefore considered not harmful to activated sludge (Reliability 2). Read-across from the source chemical,Coco fatty acids 2 -sulfoethyl ester, sodium salt CAS no 61789 -32 -0 to the target chemical is considered to be justified based upon a commonality of functional groups, constituents, breakdown products and metabolic pathways.
Therefore we consider these study endpoint results as sufficiently conservative to be taken account of in the risk assessment of lauric acid 2-sulfoethyl ester, sodium salt (sodium lauroyl isethionate) CAS No 7381-01-3.
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