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Diss Factsheets
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EC number: 202-774-7 | CAS number: 99-63-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- DuPont assigned Klimisch score. Air concentrations could not be characterized.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 962
- Report date:
- 1962
Materials and methods
- Principles of method if other than guideline:
- Four male albino rats (CR-CD), weighing initially about 275 grams, were exposed in a glass chamber of 8 litre capacity, 4 hours daily, 5 days a week, for a maximum of 10 exposures/per temperature series. In the room temperature (25 ºC) series, dry air was passed at a flow rate of 2 L/min through the test substance that was packed in a Drierite tube and into the chamber. In two additional series (60 ºC and 150 ºC), the test substance was placed in a 1 litre three-necked flask which was heated by means of an electric heating mantle controlled to the desired temperature by a Brown Electronik controller-recorder and dry air was passed over the sample at a flow rate of 2 L/min and into the glass chamber containing four rats.
A fresh sample of test substance was used each day of exposure. - GLP compliance:
- no
Test material
- Reference substance name:
- Isophthaloyl dichloride
- EC Number:
- 202-774-7
- EC Name:
- Isophthaloyl dichloride
- Cas Number:
- 99-63-8
- Molecular formula:
- C8H4Cl2O2
- IUPAC Name:
- benzene-1,3-dicarbonyl dichloride
- Details on test material:
- - Analytical purity: >99% Isophthaloyl Chloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CR-CD, albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- - Weight at study initiation: about 275 grams.
- Rats were albino.
Administration / exposure
- Route of administration:
- other: vapour and dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus, source and rate of air: In the experiment at room temperature (25 ºC) the test substance was packed in a small Drierite tube and dry air at a flow rate of 2 L/min was passed through it and into the chamber containing four rats. In the experiments with test substance heated above room temperature, the sample was placed in a 1 liter three-necked flask which was heated by means of an electric heating mantle controlled to the desired temperature by a Brown Electronik controller-recorder and dry air was passed over the sample at a flow rate of 2 L/min and into the glass chamber containing four rats.
At higher temperatures some of the test substance recondensed on the walls of the chamber and the tubing leading to it. Thus, calculations of the inhaled concentrations were not possible.
- Test material concentrations
25 ºC: 20 gm sample - some deposits of the test substance were observed on the walls of the chamber.
60 ºC: 20 gm sample - some deposits of the test substance were observed on the walls of the chamber.
150 ºC: 20 gm sample - some deposits of the test substance were observed on the walls of the chamber.
-Exposure chamber volume: 8L - Analytical verification of doses or concentrations:
- no
- Details on analytical verification of doses or concentrations:
- Concentrations could not be characterized
- Duration of treatment / exposure:
- 4 hours
- Frequency of treatment:
- 5 days/week for 2 weeks. (Ten 4-hr exposures)
Doses / concentrations
- Remarks:
- Concentrations could not be characterized
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- effects observed, treatment-related
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Histopathological findings: neoplastic:
- effects observed, treatment-related
- Details on results:
- 25 ºC x 4 hrs x 10 exposures:
Clinical signs during exposure were minimal. For the most part, rats gained weight throughout the course of the exposures and during the 14-day observation period. 2 rats were sacrificed immediately and 2 were sacrificed after a 14 day observation period.
- 2/2 rats sacrificed immediately after the tenth exposure showed moderate pulmonary congestion. 1/2 rats sacrificed 14 days later showed pulmonary congestion. 4/4 rats had increased kidney weights over controls. On microscopic examination of the lungs, a slight amount of pulmonary
edema was noted in the rats sacrificed at the end of exposure but not in those sacrificed 14 days after exposure. There was a slight increase in
pneumonitis, catarrhal alveolitis and emphysema in all exposed animals. No significant changes were detected in brain tissue. The liver showed minimal hypotrophy of cells in the area adjacent to the portal tracts.
60 ºC x 4 hrs x 10 exposures:
Clinical signs during exposure were minimal. All rats survived, and for the most part, gained weight during exposure but at a slightly reduced rate.
Two rats were sacrificed immediately after the tenth exposure. The remaining two were held for a 14-day observation but through error were discarded. Examination of the lungs of the two rats which were sacrificed revealed slight aggravation of the usual pneumonitis as well as slight edema and emphysema. A slight degree of hypotrophy of liver cells in the region adjacent to the portal tracts was noted. The kidneys revealed slight swelling of the glomeruli and slight hypotrophy of the proximal convoluted tubules.
150 ºC x 4 hrs x 5 exposures:
Clinical signs during exposure consisted of eye irritation, deep and irregular respiration and gasping. One rat died during the fourth exposure. All rats lost weight during the exposures and the survivors were sacrificed three days after the fifth exposure. When examined grossly, all rats were emaciated and dehydrated; and many of the organs appeared hypotrophic. Microscopic evaluation revealed aggravation of the usual endemic pneumonitis, relatively pronounced emphysema, focal hemmorrhates, alveolar cell desquamation, suppurative bronchiolitis and bronchopneumonia. Impairment of the liver cells was relatively pronounced. Kidney changes were qualitatively similar to those noted at 60C, but were more pronounced. There was a variably severe hyperemia of the brain.
Effect levels
- Dose descriptor:
- other: NOAEL could not be established because air concentrations could not be characterized
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Ten 4-hr exposures to air passed through the material at 25 ºC or over it at 60 ºC were not fatal and produced relatively limited pathological changes which were mainly confined to the lungs, with lesser effects on the liver and kidneys. Repeated exposures to air passed over isophthaloyl chloride at 150 ºC, however, resulted in the death of one animal during the fourth exposure. Since the remaining three rats were showing pronounced irritation, illness, and weight loss, they were sacrificed 3 days after the fifth and last exposure. Pathological changes were more severe than those noted in the other exposures. The effects of the test substance are primarily those of an irritant. It is recommended that prolonged and repeated inhalation of the dust at room temperature or of the vapours and dust at elevated temperatures be avoided, and that the concentration of the test substance in the atmosphere be kept below the level of sensory irritation.
- Executive summary:
The effects of the test substance are primarily those of an irritant. It is recommended that prolonged and repeated inhalation of the dust at room temperature or of the vapours and dust at elevated temperatures be avoided, and that the concentration of the test substance in the atmosphere be kept below the level of sensory irritation.
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