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Diss Factsheets
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EC number: 222-883-3 | CAS number: 3648-18-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
- Reference Type:
- other: Comment to CLH Proposal
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
- Objective of study:
- metabolism
- other: Hydrolysis under stomach conditions
Test guideline
- Qualifier:
- no guideline required
- GLP compliance:
- no
Test material
- Specific details on test material used for the study:
- Dioctyltin dilaurate
- Radiolabelling:
- no
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- dimeric Distannoxane
Bioaccessibility (or Bioavailability)
- Bioaccessibility (or Bioavailability) testing results:
- There is no bioavailability of the dimeric Distannoxane based on a molecular mass of > 1000 DA
Applicant's summary and conclusion
- Conclusions:
- DOTL in-vitro metabolism can be monitored using 119Sn-NMR Spectroscopy. Under the simulated gastric conditions (0.1 M HCl/pH 1.2/37°C) the tin resonance at -155 ppm characteristic to DOTL (Annex 1) disappeared completely indicating that DOTL has been used up within 0.5-4.0 hour of the experiment. Main products of the hydrolysis (Annex 2 and 3) are DOTLC, (DOTCL)2O and a DOTO complex. (DOTCL)2O was detected as two sharp peaks at -92 ppm and -145 ppm
Increasing the exposure time from 30 min. to 4 hours slightly increased the amount of DOTLC and decreased the amount of the DOTO complex (Annex 2 and 3).
Formation of the dialkytin mono-chloro carboxylates is described in literature 2). This type of hydrolytic behavior at low pH is consistent with the results obtained on hydrolysis of dialkyltinmecaptides4-6). The dialkyltin mono-chloro esters are formed under the same conditions rapidly and equilibrated with the initial dialkyltin mecaptides.
A broad signal at about 150 ppm was assigned to the DOTO complex. On one hand, the DOTO reference material results in a comparable chemical shift with a broad signal (Annex 6), on the other hand, DOTO is not known to be soluble in hexane. Therefore, the DOTO complex term in this study describes a hexane-extractable solution of DOTO in DOTLC or DOTL.
Alkyltincarboxylates are known for their rich structural variety which includes different ways of coordinating the carboxyl groups and tin atoms and their ability to form bridged chemical structures2,3). Additionally, bulky alkyl groups (such as octyl groups) on a tin atom of the dialkyltin oxides are known to form more soluble cyclic trimers as opposed to dialkyltin oxide polymers7).
Addition of a DOTC excess resulted in an instant reaction of the DOTO complex to DOTLC.
In order to check if any non-extractable by hexane tin compounds were formed as a result of DOTL in-vitro metabolism and remained in the aqueous phase, that phase was analyzed for a total tin content using AAS. The total tin content of the aqueous phase was found to be < 10 ppm (trace quantity).
In a hydrolysis study of Dioctyltin dilaurate with 0.1 M Hydrogenchloride (4h, 37 ^C) was identified a distannoxane as hydrolysis product. In an similar experiment with Dioctyltin dichloride also was identified a distannoxane as hydrolysis.
Based on 119Sn-NMR data and data from mass spectroskopy, the distannoxane is minimum monomeric with a mass > 1000 Da.
So even if formed by both substances (source and target) under low pH conditions this substance cannot pass the
membranes of the gastrointestinal tract and thus is toxicological not of relevance
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