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EC number: 439-590-3 | CAS number: 12158-75-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from March 12, 2001 to March 16, 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 439-590-3
- EC Name:
- -
- Cas Number:
- 12158-75-7
- Molecular formula:
- Cu2H3NO6
- IUPAC Name:
- copper(2+) hydroxide nitrate
- Details on test material:
- batch n°: 060248
composition of the test material: Cu=52.6% - N=5.4% - H=1.5% - O=36.8%
solubility in water: practically insoluble
expiration date of the batch: February 2002
storage conditions of test substance: ambient temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- hygiene: optimal hygienic conditions
room temperature: average of 20.3°C (continuous control and recording)
relative humidity: average of 50.8% (continuous control and recording)
air exchange: 12 per hour
light: artificial light from 6 a.m. to 6 p.m.
cages: individual caging in metal wire cages, type KK016R, with a wooden rest shelf
feed: Altromin 2023 diet for rabbits, ad libitum (producer: Altromin GmbH, D-32761 Lage) ; random samples of the feed are analysed for contaminants by Altromin ; Hay-briquettes (supplied by SSNIFF, D-59494 Soest) were offered additionally as a dietary supplement
water: tap water from an automatic watering system, ad libitum
identification: labelling with felt-tipped pen in a pinna
acclimatisation: 5 days
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: hair was clipped
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24, 48 and 72 hours after patch removal
- Number of animals:
- 3 females
- Details on study design:
- Test substance administration:
Hair was clipped on the dorsal areas of the trunks one day before the application of the test substance. the test sites were median on the dorsal thoracal region.
Samples with approximately 0.5 g of the test substance were moistened with 1 mL deionised water and were placed on cellulose patches in a size of about 2.5 cm * 2.5 cm and were applied to the test sites. They were held in place by fixing them marginally with non irritating tapes. The application sies were covered semi-occlusively by a dressing.
Access by the animals to the application sites was prevented by a plastic collar.
At the end of the exposure period, the dressings, the tapes with the patches and the collars were removed, residual test substance was wiped off with wet Kleenex-tissues, if necessary.
Skin examinations:
The skins of the animals were examined for local alterations after the clipping procedure, one day before the application and immediately before application. the treated areas and the surrounding untreated skin (control area) of the animals were examined for erythema/eschar and oedema as well as for other local alterations approximately 1, 24, 48 and 72 hours after patch removal.
No further examinations were performed thereafter.
The skin was examined using a cold light source KL1500 electronic.
General examinations:
The animals were examined once daily for other than local changes of the skin.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: erythema/eschar score
- Basis:
- mean
- Time point:
- other: mean (24-72h)
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: mean (24-72h)
- Score:
- 0
- Max. score:
- 0
- Other effects:
- No general toxic effects were noted.
Any other information on results incl. tables
A light-blue staining of the skin at the application site was seen in all animals from 1h p.a. until a maximum of 24h after patch removal, but did not impede the xamination of the skin for erythema. The discoloration is directly attributed to a staining property of the test substance and not considered to be a toxic effect. Except for this, all exposed skin sites were normal at each examination term.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test substance Copper Hydroxide Nitrate is not irritating to the skin as per EU Regulations.
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