Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 457-320-2 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Skin irritation - a precautionary classification as a skin irritant is concluded
Eye irritation - the mild degree of irritation caused by the substance is insufficient to warrant classification as an eye irritant according to CLP.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
EC# 457-320-2 has been tested for skin and eye irritation potential in GLP studies performed in accordance with OECD test guidelines 404 and 405. In the ocular irritation study, the substance caused mild, reversible irritation at levels insufficient to require classification under CLP. In the dermal irritation study, a greater degree of irritation was seen in one animal than the other two. As a precuationary measure, therefore, it is concluded the substance should be classified as a skin irritant under CLP.
Effects on skin irritation/corrosion: irritating
Justification for classification or non-classification
EC# 357-320-2 has been tested for skin and eye irritation potential in GLP studies performed in accordance with OECD test guidelines 404 and 405. In the ocular irritation study, the substance caused mild, reversible irritation at levels insufficient to require classification under CLP. In the dermal irritation study, a greater degree of irritation was seen in one animal than the other two. As a precuationary measure, therefore, it is concluded the substance should be classified as a skin irritant under CLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
