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EC number: 220-358-3 | CAS number: 2736-23-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 03-10-1980 to 10-10-1980
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,4-dichloro-5-sulphamoylbenzoic acid
- EC Number:
- 220-358-3
- EC Name:
- 2,4-dichloro-5-sulphamoylbenzoic acid
- Cas Number:
- 2736-23-4
- Molecular formula:
- C7H5Cl2NO4S
- IUPAC Name:
- 2,4-dichloro-5-sulphamoylbenzoic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- White powder
Constituent 1
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- As test water was deionized water (CHRIST-Ministil-ion exchange cartridge) with a conductivity of <5 pSicm. This water were added per liter of the following salts according to the recipe of MARKING and DAWSON:
192 mg NaHCO3
120 mg CaSO4. 2H2O
120 mg MgSO4
8 mg HCl
The experiment consisted of glass basin (40 x 25 x 30 cm) and were filled with 20 liters of test water.
Test organisms
- Test organisms (species):
- Leuciscus idus melanotus
- Details on test organisms:
- Type: golden orfe (Leuciscus idus f. melanotus)
Breeder: Paul Eggers, 2345 Hohenwestedt
Acclimatization: The fish were kept at least 14 days before the test begins at 20 °C in dechlorinated tap water.
Body weight: 2.0 - 2.8 g (x = 2.3 g; g s = 0.27, n = 10)
The determination was made at the beginning of testing.
Body length: 5,0 - 6,3 cm (x = 5.9 cm; s = 0.36 cm, n = 10)
Experimental groups: 0 / 1 / 10 / 100 / 500 mg/l
Food: Tetra Min (Tetra Werke, Melle)
Study design
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 9.5°d (Carbonate 6.4 °d)
- Test temperature:
- 20 +/- 1°C
- pH:
- 8.2 - 8.3
- Dissolved oxygen:
- The oxygen content was above 8 mg/l.
- Details on test conditions:
- The pools were aerated throughout the experimental period through glass capillaries. Approximately 100 ml of air was passed through the pool per minute.
The pools were illuminated from above in a day-night rhythm of 12 hours each. The illumination intensity was directly over the bassin approximately 700 lux
About 65 hours before the beginning of the test 10 fishs were placed in each bassin.
The test substance is poorly soluble in water and was suspended using an Ultra-Turrax for 5 minutes at maximum speed in the test water, applied in the experimental basin and spread evenly with a glass rod. Consequently, the given concentrations are not related to dissolved fractions, but on the introduced total amount of substance in the basin. Immediately before the addition of the substance, as well as after 2, 24, 48, 72 and 96 hours, the parameters pH, O2 and temperature were measured in each test pool. The measurement of the oxygen content was performed using the Oxi 39 (Scientific and Technical Workshops GmbH, Weilheim, Upper Bavaria), the temperature was measured with a mercury thermometer.
During the entire experimental period, the fish were regularly observed and the behavior recorded. After completion of the experimental period the fish were killed in dissolved 0.05% MS 222 (methanesulfonate of meta-amino benzoic acid ethyl ester, Sandoz), dissected and examined macroscopically.
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- Mortality:
During the 96-hour test period no fish died in all the tested concentration groups. The LC50 is therefore for 48 and 96 hours over 500 mg/l.
Symptoms:
The fishes of all group has the same behaviour than the control fishes.
Macroscopic findings survey:
The section of the dead fish showed no macroscopically visible changes in all groups.
Water parameters:
The pH was slightly reduced in the 100 and 500 mg/l groups (min. 7.2 at 500 mg/l, 2 hours after addition of substance) in the 1 and 10 mg/l groups the pH is different (8.1 to 8.2) as well as the oxygen concentration of all the groups (8.4 to 8.7 mg/l) are not the values of the control group.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The determination of the acute toxicity of Lasamid to ide conducted under the described experimental conditions to an LC 50 value of above 500 mg/ l after 48 or 96 hours.
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