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Diss Factsheets
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EC number: 203-685-6 | CAS number: 109-59-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 009
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-isopropoxyethanol
- EC Number:
- 203-685-6
- EC Name:
- 2-isopropoxyethanol
- Cas Number:
- 109-59-1
- Molecular formula:
- C5H12O2
- IUPAC Name:
- Propan-2-ol
- Details on test material:
- - Name of test material (as cited in study report): 2-(1-Methylethoxy)ethanol
- Molecular formula (if other than submission substance): C5H12O2
- Molecular weight (if other than submission substance): 104.15
- Analytical purity:=> 99.5%
- Impurities (identity and concentrations): water (<0.1%)
- Lot No.: 30321
- Stability under test conditions: The stability of test material was identified by analysis of the remainder.
- Storage condition of test material: under room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Japan, Inc. Atsugi
- Age at study initiation: 5 weeks old- Fasting period before study: 18 hr
- Housing: Animals were individually housed in metallic cages with wire mesh bottoms
- Diet: ad libitum
- Water: ad libitum
- Acclimation period:9 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21.0~25.0
- Humidity (%): 40.0~75.0
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12 hr dark/12 hr light
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: distilled water for injection
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 5 ml/kg b.w.
- Doses:
- 0, 2000 mg/kg b.w.
- No. of animals per sex per dose:
- 5 animals/sex/dose
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
observation: Clinical observation was performed hourly to 6 h afterwards consecutively until one hour on the dosage day and performed once a day from the next day.
weighing: Animals were weighed just prior to administration, and on Day 2, 4,8,11 and 15.
- Necropsy of survivors performed: yes - Statistics:
- The means and standard deviation were calculated body weight, t-test of Student or t-test of Aspin-Welch was conducted.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths were observed in both sexes.
- Clinical signs:
- other: Reddish urine was observed from 3 or 4 hours to the next day in both sexes in the 2000 mg/kg groups. Decreased fecal volume was observed at the next day of administration in both sexes in the 2000 mg/kg groups.
- Gross pathology:
- There were no changes in gross pathological findings in any of the treatment groups.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 values of this substance are considered as >2000 mg/kg.
- Executive summary:
A single dose oral toxicity test of 2 -isopropoxyethanol was carried out in accordance with the OECD Test Guideline 401. In this study, no deaths occurred in either sex and the LD50 values were found to be above 2000 mg/kg in both sexes. Reddish urine and decreased of body weight and fecal volume were observed in this study.
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