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EC number: 605-546-9 | CAS number: 169280-10-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 1997 - September 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study performed according to international guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4-(Cyclopropylcarbonyl)-α,α-dimethyl-ethyl ester benzeneacetic acid
- EC Number:
- 605-546-9
- Cas Number:
- 169280-10-8
- Molecular formula:
- C16 H20 O3
- IUPAC Name:
- 4-(Cyclopropylcarbonyl)-α,α-dimethyl-ethyl ester benzeneacetic acid
- Details on test material:
- Batch: Dest.3-1 of April, 1997 from PT/TTF
Appearance: yellowish solid
Date of receipt: 31 October 1997
Storage conditions: at 4ºC
Expiry date: 7 April 1999
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Breeder: Iffa Crédo, 69210 L'Arbresle, France
Number and sex: one group of 10 animals (5 males and 5 females)
Age/weight: on the day of treatment, the animals were approximately 6 weeks old and had a mean body weight of 186 +/- 8g for males and 1448 +/- 5g for the females.
Acclimatization: at least five days before the start of the study.
Temperature: 21 ± 2ºC
Relative humidity: 30 to 70%
Light/dark cycle: 12 h/12 h
Ventilation: ca. 12 cycles/hour of filtered, non-recycled air.
Housing: polycarbonate cages (48 x 27 x 20 cm), each containing four to seven animals during acclimatisation and five of the same sex during the experiment.
During the acclimatisation period and after the day of exposure in the experiment, the animals had free acces to food and water.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesam oil
- Details on oral exposure:
- Vehicle: The substance was grinded and mixed with sesam oil prior to dosing. Homogeneity was determined by chemical analysis and guanranteed for at least 4 hours.
Dosing: volume of 10 ml/kg
Gavage: stainless steel probe fitted to a 2 ml glass syringe
Fasting: animals were deprived of food for 18 hours prior to dosing - Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- other: Historical data on control animals
- Details on study design:
- The substance was administered to the rats as a single dose followed by 14 days of observation.
- Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed.
- Clinical signs:
- other: Hypoactivity and piloerection in 2/5 males and 3/5 females on day 1 only. No others clinical signs were noted.
- Gross pathology:
- No abnormalities.
- Other findings:
- No other findings.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the experimental conditions, the oral LD50 is greater than 2000 mg/kg in rats.
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