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EC number: 289-296-2 | CAS number: 87061-04-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental starting date: 27 March 2017 Experimental completion date: 06 April 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- The sample solutions were taken from the waterbath at various times and the pH of each solution recorded.
The concentration of the sample solution was determined by high performance liquid chromatography (HPLC). - Buffers:
- Plase see section below "Any other information on materials and methods, incs. table"
- Details on test conditions:
- Performance of the Test
Preparation of the Test Solutions
Sample solutions were prepared in stoppered glass flasks at a nominal concentration of 1.0 g/L in the three buffer solutions.
The test solutions were split into individual vessels for each data point.
The solutions were shielded from light whilst maintained at the test temperature.
Preliminary Test/Tier 1
Sample solutions at pH 4, 7 and 9 were maintained at 50.0 ± 0.5 °C for a period of 144 hours. - Duration:
- 144 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 1.02 - <= 1.04 g/L
- Duration:
- 144 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 0.927 - <= 0.96 g/L
- Duration:
- 144 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 0.975 - <= 0.983 g/L
- Number of replicates:
- 2
- Positive controls:
- no
- Negative controls:
- yes
- Remarks:
- Matrix blanks Acetonitrile: relevant buffer (1:1 v/v)
- Statistical methods:
- Evaluation of Data
The absorbance and concentration of each standard solution were plotted on a calibration curve (first order) and the sample concentrations then interpolated from this curve. The concentrations were then corrected for dilution factor (200). - Preliminary study:
- No significant peaks were observed at the approximate retention time of the test item on analysis of any matrix blank solutions.
As the test item was determined to be hydrolytically stable under all conditions (t½ > 1 year at 25 °C), no additional testing was performed. - Test performance:
- Validation
The detector response with respect to concentration was assessed over the nominal concentration range of 0.5 to 7.5 mg/L (all pH’s). The results were satisfactory with correlation coefficients (r) of ≥ 1.000 being obtained. The detector response for all pH’s was a quadratic fit, therefore a multi-point calibration was run with each set of samples, using matrix matched standards. - Transformation products:
- no
- Details on hydrolysis and appearance of transformation product(s):
- Substance was detrmined to be hydrolytically stable under all conditions.
- Key result
- pH:
- 4
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 h-1
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- hydrolytically stable based on preliminary test
- Remarks:
- Estimated rate constant at 25°C
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 h-1
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- hydrolytically stable based on preliminary test
- Remarks:
- Estimated rate constant at 25°C
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 h-1
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- hydrolytically stable based on preliminary test
- Remarks:
- Estimated rate constant at 25°C
- Details on results:
- Please refer below to "Any other information on results incs. tables"
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test item was determined to be hydrolytically stable under all conditions (t½ > 1 year at 25 °C).
- Executive summary:
The abiotic degradation, hydrolysis as a function of pH of COOLACT 10 was carried out using a procedure designed to be compatible with Method C.7 Abiotic Degradation, Hydrolysis as a Function of pH of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004 and REACH Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006. The results are as follows:
pH
Half-Life at 25 °C
4
>1 year
7
>1 year
9
>1 year
Reference
Preliminary Test/Tier 1
The mean peak areas relating to the standard and sample solutions are shown in the following table:
Preliminary Testing pH 4 at 50.0 ± 0.5 °C
Solution |
Mean peak area |
||
Standard 0.529 mg/L |
3.66 x 105 |
||
Standard 1.59 mg/L |
1.11 x 106 |
||
Standard 2.65 mg/L |
1.81 x 106 |
||
Standard 3.70 mg/L |
2.53 x 106 |
||
Standard 4.76 mg/L |
3.27 x 106 |
||
Standard 5.30 mg/L |
3.69 x 106 |
||
Standard 5.82 mg/L |
3.98 x 106 |
||
Standard 6.88 mg/L |
4.72 x 106 |
||
Standard 7.94 mg/L |
5.43 x 106 |
||
Initial Sample A, pH 4 |
3.51 x 106 |
||
Initial Sample B, pH 4 |
3.57 x 106 |
||
24 Hour Sample A, pH 4 |
3.62 x 106 |
||
24 Hour Sample B, pH 4 |
3.57 x 106 |
||
120 Hour Sample A, pH 4 |
3.63 x 106 |
||
120 Hour Sample B, pH 4 |
3.61 x 106 |
||
144 Hour Sample A, pH 4 |
3.71 x 106 |
||
144 Hour Sample B, pH 4 |
3.70 x 106 |
Preliminary Testing pH 7 at 50.0 ± 0.5 °C
Solution |
Mean peak area |
||
Standard 0.569 mg/L |
5.06 x 105 |
||
Standard 1.71 mg/L |
1.47 x 106 |
||
Standard 2.84 mg/L |
2.34 x 106 |
||
Standard 3.98 mg/L |
3.25 x 106 |
||
Standard 5.12 mg/L |
4.04 x 106 |
||
Standard 5.01 mg/L |
4.03 x 106 |
||
Standard 6.27 mg/L |
4.98 x 106 |
||
Standard 7.39 mg/L |
5.82 x 106 |
||
Standard 8.53 mg/L |
6.60 x 106 |
||
Initial Sample A, pH 7 |
3.86 x 106 |
||
Initial Sample B, pH 7 |
3.73 x 106 |
||
24 Hour Sample A, pH 7 |
3.90 x 106 |
||
24 Hour Sample B, pH 7 |
3.95 x 106 |
||
120 Hour Sample A, pH 7 |
3.86 x 106 |
||
120 Hour Sample B, pH 7 |
3.84 x 106 |
||
144 Hour Sample A, pH 7 |
3.92 x 106 |
||
144 Hour Sample B, pH 7 |
3.95 x 106 |
Preliminary Testing pH 9 at 50.0 ± 0.5 °C
Solution |
Mean peak area |
||
Standard 0.511 mg/L |
4.28 x 105 |
||
Standard 1.53 mg/L |
1.27 x 106 |
||
Standard 2.55 mg/L |
2.08 x 106 |
||
Standard 3.58 mg/L |
2.88 x 106 |
||
Standard 4.60 mg/L |
3.67 x 106 |
||
Standard 5.18 mg/L |
4.00 x 106 |
||
Standard 5.62 mg/L |
4.42 x 106 |
||
Standard 6.64 mg/L |
5.09 x 106 |
||
Standard 7.66 mg/L |
5.75 x 106 |
||
Initial Sample A, pH 9 |
3.85 x 106 |
||
Initial Sample B, pH 9 |
3.87 x 106 |
||
24 Hour Sample A, pH 9 |
3.75 x 106 |
||
24 Hour Sample B, pH 9 |
3.86 x 106 |
||
120 Hour Sample A, pH 9 |
3.94 x 106 |
||
120 Hour Sample B, pH 9 |
3.93 x 106 |
||
144 Hour Sample A, pH 9 |
3.85 x 106 |
||
144 Hour Sample B, pH 9 |
3.97 x 106 |
The test item concentrations at the given time points are shown in the following tables:
pH 4 at 50.0 ± 0.5 ºC
Time (Hours) |
Concentration (g/L) |
% of mean initial concentration |
|||||||
A |
B |
A |
B |
||||||
0 |
1.02 |
1.04 |
- |
- |
|||||
24 |
1.05 |
1.04 |
102.5 |
100.8 |
|||||
120 |
1.06 |
1.05 |
102.8 |
102.0 |
|||||
144 |
1.08 |
1.08 |
105.0 |
104.6 |
Result: Less than 10% hydrolysis after 5 days at 50 °C, equivalent to a half-life greater than 1 year at 25 °C.
pH 7 at 50.0 ± 0.5 ºC
Time (Hours) |
Concentration (g/L) |
% of mean initial concentration |
|||||||
A |
B |
A |
B |
||||||
0 |
0.960 |
0.927 |
- |
- |
|||||
24 |
0.972 |
0.983 |
103.0 |
104.2 |
|||||
120 |
0.961 |
0.954 |
101.9 |
101.2 |
|||||
144 |
0.976 |
0.984 |
103.5 |
104.3 |
Result: Less than 10% hydrolysis after 5 days at 50 °C, equivalent to a half-life greater than 1 year at 25 °C.
pH 9 at 50.0 ± 0.5 ºC
Time (Hours) |
Concentration (g/L) |
% of mean initial concentration |
|||||||
A |
B |
A |
B |
||||||
0 |
0.975 |
0.983 |
- |
- |
|||||
24 |
0.949 |
0.978 |
96.9 |
99.9 |
|||||
120 |
1.00 |
0.999 |
102.3 |
102.0 |
|||||
144 |
0.976 |
1.01 |
99.7 |
103.2 |
Result: Less than 10% hydrolysis after 5 days at 50 °C, equivalent to a half-life greater than 1 year at 25 °C.
Description of key information
No significant peaks were observed at the approximate retention time of the test item on analysis of any matrix blank solutions.
As the test item was determined to be hydrolytically stable underallconditions (t½ > 1 year at 25 °C), no additional testing was performed.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
The estimated rate constant and half-life at 25 °C of the test item are shown in the following table:
pH |
Estimated rate constant (hr-1) at 25°C |
Half-life at 25 °C |
4 |
- |
> 1 year |
7 |
- |
> 1 year |
9 |
- |
> 1 year |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.