Registration Dossier
Registration Dossier
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EC number: 203-137-6 | CAS number: 103-71-9
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: sufficient documented for evaluation
Data source
Reference
- Reference Type:
- publication
- Title:
- Patch-test reactions to plastic and glue allergens
- Author:
- Kanerva L, Jolanki R, Alanko K, Estlander T
- Year:
- 1 999
- Bibliographic source:
- Acta Derm Venerol 79, 296-300
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- survey
- Principles of method if other than guideline:
- patch-test
- GLP compliance:
- no
Test material
- Reference substance name:
- Phenyl isocyanate
- EC Number:
- 203-137-6
- EC Name:
- Phenyl isocyanate
- Cas Number:
- 103-71-9
- Molecular formula:
- C7H5NO
- IUPAC Name:
- isocyanatobenzene
Constituent 1
Method
- Type of population:
- occupational
- Route of administration:
- dermal
Results and discussion
- Results of examinations:
- not sensitising
Any other information on results incl. tables
0 out of 310 worker tested in a patch test showed an allergic reaction - but in 3 of 310 worker an irritant reaction was evident
Applicant's summary and conclusion
- Executive summary:
310 worker occupied in the production of polyurethanes were patch tested with phenyl isocyanate (0.1% solution in petrolatum).
0 out of 310 worker tested showed an allergic reaction - but in 3 of 310 worker an irritant reaction was evident
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