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Diss Factsheets
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EC number: 202-090-9 | CAS number: 91-68-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable and valid study, limited documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 957
- Report date:
- 1957
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method: BASF-Test ("Zeittest" 1, 5 , 15 min and 20 h test item exposure on skin and ear)
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-diethylaminophenol
- EC Number:
- 202-090-9
- EC Name:
- 3-diethylaminophenol
- Cas Number:
- 91-68-9
- Molecular formula:
- C10H15NO
- IUPAC Name:
- 3-(diethylamino)phenol
- Details on test material:
- - Name of test material (as cited in study report): Diäthyl-m-aminophenol
- Physical state: solid
- Analytical purity: 99 %
- Other: soluble in acetic acid, alcohol, lutrol, ethylenechloride, unsoluble in soda solution and vegetable oil
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- other: water or alcohol
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: the application site was covered with powdered and moistened test substance
- Concentration: 50 % in water (pulp) or 50 % in alcohol (almost dissolved) - Duration of treatment / exposure:
- - 1, 5, 15 min and 20 h
- Observation period:
- 7- 14 days
- Number of animals:
- - 2 animals per time point
- Details on study design:
- Before OECD Guideline 404 was established in 1982, skin irritation was tested using an internal method (BASF test).
White Vienna rabbits were used. Usually, 2 animals were treated for 1, 5 and 15 minutes and 2 other animals for 20 hours using occlusive conditions. An application site of 2.5 X 2.5 cm was covered with the powdered and moistened test substance. In addition, skin tissue from the ear was tested by wrapping the ear.
After the application time of 1, 5 or 15 min, the skin was washed with Lutrol conc and Lutrol 50 % in water.
The skin exposed 20 h to the test substance remained unwashed after application.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- Exposure time 20 hours
- Basis:
- animal #1
- Remarks:
- 50% in water
- Time point:
- other: within 14 days
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48h
- Remarks:
- slight dequamation on d4
- Irritation parameter:
- edema score
- Remarks:
- Exposure time 20 hours
- Basis:
- animal #1
- Remarks:
- 50% in water
- Time point:
- other: within 14 days
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- erythema score
- Remarks:
- Exposure time 20 hours
- Basis:
- animal #2
- Remarks:
- 50% in water
- Time point:
- other: within 14 days
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks:
- discoloration
- Irritation parameter:
- edema score
- Remarks:
- Exposure time 20 hours
- Basis:
- animal #2
- Remarks:
- 50% in water
- Time point:
- other: within 14 days
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- erythema score
- Remarks:
- Exposure time 20 hours
- Basis:
- animal #1
- Remarks:
- 50% in alcohol
- Time point:
- other: within 14 days
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks:
- discoloration
- Irritation parameter:
- edema score
- Remarks:
- Exposure time 20 hours
- Basis:
- animal #1
- Remarks:
- 50% in alcohol
- Time point:
- other: within 14 days
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- erythema score
- Remarks:
- Exposure time 20 hours
- Basis:
- animal #2
- Remarks:
- 50% in alcohol
- Time point:
- other: within 14 days
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 9d
- Remarks:
- slight desquamation on d9
- Irritation parameter:
- edema score
- Remarks:
- Exposure time 20 hours
- Basis:
- animal #2
- Remarks:
- 50% in alcohol
- Time point:
- other: within 14 days
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 9d
Any other information on results incl. tables
The following table shows an overview of the obtained results in the irritation tests.
Erythema and edema were scored immediately after exposure period.
Concentration | Animal | Skin | |||
1 min | 5 min | 15 min | 20 h | ||
50 % in water | 1 | Erythema: 1 fully reversible within 24h | Erythema: 1 fully reversible within 24h ; slight desquamation on d4 | Erythema: 1 fully reversible within 24h; slight desquamation on d4 | Erythema: 1 fully reversible within 48h; slight desquamation on d4 |
2 | No skin findings | No skin findings | No skin findings | discoloration No further skin findings | |
50 % in alcohol | 1 | Erythema: 2 slight desquamation on d5 | Erythema: 2 slight desquamation on d5 | Erythema: 2 fully reversible within 5d | discoloration No further skin findings |
2 | Erythema: 1 fully reversible within 5d | Erythema: 1 fully reversible within 5d | Erythema: 2 small patchy necrotic area; no skin findings on d14 | Erythema: 3 Edema:3 fully reversible within 9d; slight desquamation on d9 |
Ø no symptom
1 indicated erythema
2 slight erythema
3 well defined erythema
3 well defined edema
4 severe erythema
Findings in ear:
Application for 20 hours in water resulted in no findings.
Application for 20 hours in alcohol resulted in discoloration and erythema (2), beeing reversible within 4 days.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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