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EC number: 201-933-8 | CAS number: 89-72-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20/05/1991-01/06/1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Study has been conducted according to valid study guidelines. Deviations are in the number of fish per concentration and in the absent analytical confirmation of nominal concentrations. This is not expected to compromise the quality of the study results.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- yes
- Remarks:
- Deviations are in the number of fish per concentration and in the absent analytical confirmation of nominal concentrations. This is not expected to compromise the quality of the study results.
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- - Method of preparation: direct dispersion in water
- Media renewal: daily - Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: Rainbow trout
- Source: Parkwood Trout Farm, Kent, UK
- Length at study initiation: 4.1 ± 0.2 cm
- Weight at study initiation: 1.05 ± 0.13
ACCLIMATION
- Health during acclimation (any mortality observed): Mortality zero in the 7 days prior to the start of the test
- Medication: none
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- 24, 48 and 72 h
- Hardness:
- Approximately 50 mg/l as CaCO3
- Test temperature:
- 14°C
- pH:
- not reported
- Dissolved oxygen:
- aeration: yes
- Salinity:
- fresh water study
- Nominal and measured concentrations:
- Range Finding Study: 1.0, 10 and 100 mg/l
Definitive Study: 1.0 mg/l
only nominal concentrations reported - Details on test conditions:
- Medication: none
Test Vessels: 20 l
Loading: 0.53 g bodyweight/litre
Test water: dechlorinated tap water (sodium thiosulphate) - Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Sublethal observations / clinical signs:
Range Finding Study
Dates: 20 -24 may 1991
Concentration
(mg/l)
Cumulative Mortality (initial population = 3)
24 Hours 48 Hours 72 Hours 96 Hours Control 0 0 0 0 1.0 0 0 0 0 10 2 2 2 2 100 2 2 2 2 Definitive Study
Dates: 28 May - 1 June 1991
Concentration
(mg/l)
Cumulative Mortality (initial population = 10)
24 Hours
48 Hours
72 Hours
96 Hours
Control
0
0
0
0
1.0 R1
0
0
0
0
1.0 R2
0
0
0
0
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test substance is toxic to fish upon short-term exposure.
- Executive summary:
A study was perform to assess the acute aquatic toxicity of the test material phenol 2 -(1-methylpropyl). The method followed the OECD Guidelines for Testing of Chemicals No. 203 "Fish, Acute Toxicity Test. Deviations are in the number of fish per concentration and in the absent analytical confirmation of nominal concentrations (this is not expected to compromise the quality of the study results). The screening 96 h acute toxicity study was conducted with rainbow trout at nominal test concentrations of 1.0, 10 and 100 mg/l. The number of fish was 3 per test concentration in a preliminary study. In the final study, the number of fish was 10 in two replicates at 1.0 mg/l. In parallel a control group were tested. Mortality ocurred (2) in the range finding study at 10 and 100 mg/l concentration. The LC50 at 96 hours exposure was determined to be >1 mg/l. The test substance is toxic to fish upon short-term exposure.
Reference
Description of key information
LC50 at 96 hours >1 mg/L (OECD 203)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 mg/L
Additional information
Phenol 2 -(1-methylpropyl) was evaluated for its aquatic toxicity. The LC50 at 96 hours exposure was determined to be >1 mg/l. The test substance is toxic to fish upon short-term exposure.
Test method:
The method followed the OECD Guidelines for Testing of Chemicals No. 203 "Fish, Acute Toxicity Test. Deviations are in the number of fish per concentration and in the absent analytical confirmation of nominal concentrations (this is not expected to compromise the quality of the study results). The screening 96 h acute toxicity study was conducted with rainbow trout at nominal test concentrations of 1.0, 10 and 100 mg/l. The number of fish was 3 per test concentration in a preliminary study. In the final study, the number of fish was 10 in two replicates at 1.0 mg/l. In parallel a control group were tested. Mortality ocurred (2) in the range finding study at 10 and 100 mg/l concentration.
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