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EC number: 208-063-8 | CAS number: 507-09-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Thioacetic acid
- EC Number:
- 208-063-8
- EC Name:
- Thioacetic acid
- Cas Number:
- 507-09-5
- Molecular formula:
- C2H4OS
- IUPAC Name:
- ethanethioic S-acid
- Test material form:
- other: liquid
- Details on test material:
-
- Name of test material (as cited in study report): Thioacetic acid
- batch AOGHJU,
- purity 99.58%.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Iffa Crédo, 69210 L'Arbresle, France.
- Age at study initiation: approximately 6 weeks old
- Weight at study initiation: 176 ± 4 g for the males and 143 ± 6 g for the females
- Fasting period before study:
- Housing: in polycarbonate cages (48 cm x 27 cm x 20 cm). Each cage contained one to seven animals of the same sex during the acclimatization period and five rats of the same sex during the treatment period
- Diet/ A04 C pelleted diet ad libitum
- Water: Drinking water filtered by a FG Millipore membrane (0.22 micron) was provided ad libitum.
- Acclimation period: at !east 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 ± 2
- Humidity (%): 30 to 70
- Air changes (per hr): 12
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg
- Doses:
- 200, 350, 500 and 1000 mg/kg
- No. of animals per sex per dose:
- 4 groups of five males or five females were used
- Control animals:
- no
- Details on study design:
- Clinical signs, mortality and body weight gain were checked for a period of up to 14 days following the single administration of the test substance. All animals were subjected to necropsy.
- Statistics:
- None
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 200 - 350 mg/kg bw
- Mortality:
- At the 200 mg/kg dose-level, no mortality were recorded.
At the 350, 500 and 1000 mg/kg dose-levels, all animals died within 24 hours following treatment. - Clinical signs:
- other: At the 200 mg/kg dose-level, no clinical signs were recorded. At the 350, 500 and 1000 mg/kg dose-levels, hypoactivity or sedation, piloerection, dyspnea, lateral recumbency, tonic-clonic convulsions and hypersalivation were the clinical signs observed pr
- Gross pathology:
- At necropsy, a whitish coloration of the stomach and intestines was noted in the animals given 1000 mg/kg. No apparent abnormalities were observed in the other animals.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 of the test substance THIOACETIC ACID is comprised between 200 and 350 mg/kg, in female rats.
- Executive summary:
The acute oral toxicity of the THIOACETIC ACID was evaluated in rats according to OECD (No. 401, 24th February 1987) and EC (92/69/EEC, B.l, 31st July 1992) guidelines. The study was conducted in compliance with the principles of Good Laboratory Practice Regulations. The test substance was administered by oral route (gavage) to groups of five male or five female fasted Sprague-Dawley rats. The test substance was prepared in corn oil and administered to the animals under a volume of 10 ml/kg. The study design was as follows:
Dose
(mg/kg)
Vehicle
Volume (ml/kg)
Male
Female
200
corn oil
10
5
350
corn oil
10
5
500
corn oil
10
5
1000
corn oil
10
5
Clinical signs, mortality and body weight gain were checked for a period of up to 14 days following the single administration of the test substance. All animals were subjected to necropsy.
At the 200 mg/kg dose-level, no clinical signs and no mortality were recorded. At the 350, 500 and 1000 mg/kg dose-levels, all animals died within 24 hours following treatment. Hypoactivity or sedation, piloerection, dyspnea, lateral recumbency, tonic-clonic convulsions and hypersalivation were the clinical signs observed prior to death. The body weight gain of the surviving animals given 200 mg/kg was not affected by treatment with the test substance. At necropsy, a whitish coloration of the stomach and intestines was noted in the animals given 1000 mg/kg. No apparent abnormalities were observed in the other animals.
The oral LD50 of the test substance THIOACETIC ACID is comprised between 200 and 350 mg/kg, in female rats.
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