Registration Dossier
Registration Dossier
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EC number: 238-056-5 | CAS number: 14205-39-1
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
- Principles of method if other than guideline:
- Method according to Kimmerle, G.; Eben, A.: Arch. Toxicology 30, 115, 1973
One group of 10 male and female rats was subjected to a single 4-hour head-nose exposure at a technically maximal feasible dust concentration and observed for mortality, body weights, clinical signs and gross pathological changes through day 14. - GLP compliance:
- no
- Test type:
- other: acute inhalation toxicity, rat
- Limit test:
- yes
Test material
- Reference substance name:
- Methyl 3-aminocrotonate
- EC Number:
- 238-056-5
- EC Name:
- Methyl 3-aminocrotonate
- Cas Number:
- 14205-39-1
- Molecular formula:
- C5 H9 O2 N
- IUPAC Name:
- methyl 3-aminocrotonate
- Details on test material:
- 3-Aminocrotonsäuremethylester, dust, content not certified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose/head only
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- nominal: 20 mg/m3
analytical: 23 mg/m3 - No. of animals per sex per dose:
- 10
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 23 mg/m³ air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
Any other information on results incl. tables
No mortality and no clinical signs occurred, growth was unaffected.
Necropsy at day 14 revealed no test substance-induced abnormalities.
Applicant's summary and conclusion
- Executive summary:
The acute inhalation toxicity of methyl 3 -aminocrotonate was determined in male and female rats via single 4-hour head-nose exposure with a technically maximal feasible dust concentration of 23 mg/m3 and a 14 days observation period.
No mortality and clinical signs occurred and therefore, the acute inhalation toxicity was > 23 mg/m3.
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