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Diss Factsheets
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EC number: 203-802-0 | CAS number: 110-77-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009-11-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to the appropriate OECD guideline and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Guideline:
- other: OECD 437 (BCOP)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- ethylthioethanol
- IUPAC Name:
- ethylthioethanol
- Reference substance name:
- 2-(ethylthio)ethanol
- EC Number:
- 203-802-0
- EC Name:
- 2-(ethylthio)ethanol
- Cas Number:
- 110-77-0
- Molecular formula:
- C4H10OS
- IUPAC Name:
- 2-(ethylsulfanyl)ethan-1-ol
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- other: cow
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
in vitro - not applicable.
Bovine cornea.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: negative and positive control groups
- Amount / concentration applied:
- 750 ul
- Duration of treatment / exposure:
- 10 minutes contact
- Observation period (in vivo):
- n/a
- Number of animals or in vitro replicates:
- 3 corneas per group (TS, negative and positive controls)
- Details on study design:
- The assay uses isolated bovine corneas as a means of assessing the ocular corrosivity or severe irritancy potential of test substances in vitro. The isolated corneas were obtained as a by-product of the meat production industry. Two endpoints, corneal opacity and permeability, were measured and combined to give an In Vitro Irritancy Score which can be used to classify and rank test substances as potential eye irritants according to OECD guideline 437.
Corneas were treated in triplicate with either the test substance (neat), positive control (ethanol 100%) or negative control (0.9% sodium chloride solution). 750 ul was introduced into the anterior part of each holder. The anterior compartment was then plugged and the holder turned to a horizontal position and rotated to ensure distribution of the test substance over the corneal surface. Contact was maintained for 10 minutes.
Opacity was determined before and after treatment using an Opacitometer to measure light transmission. The change in opacity was calculated by subtracting the initial value from the post-treatment value and correcting for the mean change in opacity for the negative control.
Permeability was determined using sodium fluorescein. The corrected permeability value was similarly determined by subtracting the mean negative control value.
The in vitro irritancy score (IVIS) = corrected opacity value + (15x corrected permeability value). IVIS >= 55.1 indicates corrosive (severe irritant).
The positive control should elicit an In Vitro Irritancy Score that falls within two standard deviations of the historical mean for the laboratory. The negative control mean opacity change value should be <=2.0 and the permeability mean value <=0.1.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: IVIS
- Basis:
- mean
- Remarks:
- 3 in vitro bovine corneas
- Time point:
- other: n/a
- Score:
- 107
- Irritant / corrosive response data:
- The test substance, ethylthioethanol, elicited an In Vitro Irritancy Score (IVIS) of 107.0 ± 15.1 and was predicted to be a corrosive/severe eye irritant.
Positive control IVIS = 49.0 +/- 6 (within 2 standard deviations of the historical range: 31.1-63.6)
Negative control IVIS = -0.333 (below the maximum acceptable value of 2.0)
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- A limited in vitro study, conducted in bovine cornea according to the guideline (OECD 437) and GLP, reported an In Vitro Irritancy Score of 107 indicating that the test material was likely to cause corrosion or severe irritation to the eyes.
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