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EC number: 601-145-8 | CAS number: 111974-73-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Guideline:
- other: Modified version of the ear/flank technique of Svens (1967)
- Principles of method if other than guideline:
- Ten female guinea pigs were used (6 test and 4 control).
Induction: Approx 0.1 ml of a 10% (w/v) solution of the test substance in DMF was applied to the outer surface of the ears of the test animals on days 1, 2 and 3. Controls were treated with DMF.
Challenge: on Day 8, immediately prior to the challenge applications, an area of all ten animals was klipped free of hair. Three concentrations of the test substance (10%, 1% and 0.1% w/v solutions in DMF) were used for the challenge. 24 h later the animals were examined and any eythema present at the challenge sites was rated on a four-point scale. - GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- phenyl N-[2-(phenylsulfanyl)phenyl]carbamate
- EC Number:
- 601-145-8
- Cas Number:
- 111974-73-3
- Molecular formula:
- C19H15NO2S
- IUPAC Name:
- phenyl N-[2-(phenylsulfanyl)phenyl]carbamate
- Test material form:
- solid: crystalline
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- female
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: dermal application
- Vehicle:
- other: dimethylformamide
- Concentration / amount:
- Induction: 10% w/v
Challenge: 10%, 1% and 0.1% w/v)
Challengeopen allclose all
- Route:
- other: dermal application
- Vehicle:
- other: dimethylformamide
- Concentration / amount:
- Induction: 10% w/v
Challenge: 10%, 1% and 0.1% w/v)
- No. of animals per dose:
- 6
- Details on study design:
- Modified version of the ear/flank technique of Svens (1967). Ten female guinea pigs were used (6 test and 4 control).
Induction: Approx 0.1 ml of a 10% (w/v) solution of the test substance in DMF was applied to the outer surface of the ears of the test animals on days 1, 2 and 3. Controls were treated with DMF.
Challenge: on Day 8, immediately prior to the challenge applications, an area approx 1 cm x 5 cm on each flank of all ten animals was clipped free of hair with a pair of veterinary clippers. Three concentrations of the test substance (10%, 1% and 0.1% w/v solutions in DMF) were used for the challenge. Approx 0.05 ml of each solution was applied, using a glass Pasteur pipette, to separate 1 cm diameter circular areas on both flanks of all ten guinea pigs. 24 h later the animals were examined and any eythema present at the challenge sites was rated on a four-point scale. Any erythema in the pre-treated animals in excess of that in the controls was considered to denote strong skin sensitisation. - Challenge controls:
- 4
- Positive control substance(s):
- no
Results and discussion
Any other information on results incl. tables
None of the animals, test or control, showed any erythematous response following challenge with 0.1, 1 or 10% (w/v) solutions of the test substance in DMF.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Not a strong skin sensitiser in the guinea pig.
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