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EC number: 616-291-8 | CAS number: 76114-73-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997-02-7 to 1997-05-15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well documented GLP based study according to EPA guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.4470 (Acute Dermal Irritation)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-propynyl-butylcarbamate
- EC Number:
- 616-291-8
- Cas Number:
- 76114-73-3
- Molecular formula:
- C8H13NO2
- IUPAC Name:
- 2-propynyl-butylcarbamate
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): only common name based on sponsor informaion is given, equivalent to:
Chemical name: Carbarmic acid, N-butyl-,2-propyn-1-yl ester
CAS: 76114-73-3
- Analytical purity: no data available
- Impurities (identity and concentrations): no data available
- Lot/batch No.: no data available
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Davidson Mill Breeding Laboratories in Jamesburg, New Jersey
- Age at study initiation: 3 month
- Weight at study initiation: 1.8 to 2.2 kg
- Housing: individually in stainless steel cages
- Diet: ad libitum Lab Diet Certified Rabbit Diet 5322
- Water: ad libitum
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18.3 - 23.8 °C (65° to 75° F)
- Humidity (%): was monitored,
- Photoperiod (hrs dark / hrs light): 12/12
:
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): single dermal application of 0.5 ml of test article to appox. 6 square centimeters
VEHICLE
- no vehicle - Duration of treatment / exposure:
- The test article was removed four hours following application.
- Observation period:
- 14 days
- Number of animals:
- 3 males (M) and 3 females (F)
- Details on study design:
- TEST SITE
- Area of exposure: 6 cm² at mid-dorsal area of the trunk, between scalpulae and pelvis
- Hair were clipped with Oster (R) small animal clipper
- Test article was covered with square surgical gauze pad (Johnson & Johnson gauze sponge) which was hold with three hypo-allergenic cloth tapes (Johnson & Johnson Dermicel)
REMOVAL OF TEST SUBSTANCE
- Washing: gently with water and paper towels
- Time after start of exposure: 4h
SCORING SYSTEM: Draize skin scoring scale
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: up to 14 days
- Score:
- 0.42
- Remarks on result:
- other: mean score from all readings were averaged
- Irritant / corrosive response data:
- Some animals showed temporary very slight erythema as well as well-defined erythema, but all irritations subssided by 14 days. No relevant edema were observed. Hence, minimal to mild, transient irritation was noted. The animals did not exhibit any abnormal clinical signs for the duration of the study.
Any other information on results incl. tables
ER: Erythema
0: No Erythema
1: Very slight erythema
2: Well-defined erythema
Rabbit Number | 4 h No. ER | 24 h No. ER | 48 h No. ER |
72 h No. ER | 7 d No. ER | 14 d No. ER |
1 | 1 | 1 | 2 | 1 | 0 | 0 |
2 | 0 | 0 | 1 | 0 | 0 | 0 |
3 | 0 | 0 | 2 | 2 | 1 | 0 |
4 | 0 | 0 | 0 | 0 | 0 | 0 |
5 | 1 | 1 | 0 | 0 | 0 | 0 |
6 | 1 | 0 | 0 | 0 | 0 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The estimated primary irritation index is 0.42. Minimal to mild, transient irritation was noted. All induced erythema subsided within 14 days after exposure. The animals did not exhibit any abnormal clinical signs for the duration of the study.
According to EU classification, the item does not has to be classified
According to GHS classification, the item does not has to be classified - Executive summary:
The dermal irritation of Propargyl-N-butylcarbamat
was determined in rabbits according to the EPA guideline EPA OTS 798.4470 (Acute Dermal Irritation). The scoring was done in accordance with the method of Draize. The estimated primary irritation index was 0.42 and hence minimal to mild, transient irritation was noted. All induced erythema subsided within 14 days after exposure. The animals did not exhibit any abnormal clinical signs for the duration of the study.The results showed short term mild irritation. The limits for classification were not surpassed. Concluding, Propargyl-N-butylcarbamat
does not have to be classified as skin irritant.
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