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Diss Factsheets
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EC number: 206-674-4 | CAS number: 366-18-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- An amount of the test item was applied as aqueous paste to the shorn back of three female rats and covered with an occlusive dressing for 24 h. Subsequently, the dressing was removed, the skin was washed with water and soap and the test item was reapplied 24 h later.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,2'-bipyridyl
- EC Number:
- 206-674-4
- EC Name:
- 2,2'-bipyridyl
- Cas Number:
- 366-18-7
- Molecular formula:
- C10H8N2
- IUPAC Name:
- 2,2'-bipyridine
- Details on test material:
- - Name of test material (as cited in study report): 2,2'-bipyridyl
- Substance type: yellowish-fawn crystalline solid
- Physical state: solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 185-195 g
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Remarks:
- as aqueous paste
- Controls:
- not specified
- Duration of treatment / exposure:
- At least six applications with an exposure time of 24 h each.
- Number of animals:
- 3
Results and discussion
In vivo
Results
- Irritation parameter:
- other: No scoring system was used
- Basis:
- other: All animals assessed
- Time point:
- other: 24h
- Reversibility:
- no data
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- No scoring system was used, however, severe erythema were observed after the first 24 h application. After 6 application cycles, also desquamination was observed.
- Irritant / corrosive response data:
- Severe erythema were observed after the first 24 h application. After 6 application cycles, also desquamination was observed.
- Other effects:
- Tremors were observed only after the first application. Necropsy and histopathological examination revealed no abnormalities of liver, kidney, thymus, lung, and skin.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Based on the effects stated in the report, a conclusion on irritating effects of the test item to the skin cannot be drawn due to the significantly prolonged exposure time.
- Executive summary:
Skin irritating properties of 2,2'- bipyridine were assessed by applying the test item as aqueous paste to the clipped skin of 3 female rats for 24 h under occlusive dressing. Subsequently, the dressing was removed, the application site was washed and the procedure was repeated. The study neither was performed according to a guideline nor under GLP.
In all rats, severe erythema were observed at the application site after the first application. At the sixth application cycle, desquamination was additionally observed. Tremors were observed only after the first application. Necropsy and histopathological examination revealed no abnormalities.
Based on the effects stated in the report, a conclusion on irritating effects of the test item to the skin cannot be drawn due to the significantly prolonged exposure time. A first evalution occured only after 24 h vs. 4 h according to OECD guideline. Furthermore, the test substance was re- applied for six consecutive days not allowing for an observation period.
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