Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 617-834-1 | CAS number: 863329-69-5
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Reliability:
- 1 (reliable without restriction)
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No experimental determination possible because test substance is insoluble in water. Therefore estimation based on hydrolysis data for structurally similar substance.
- GLP compliance:
- no
Test material
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- no
Results and discussion
- Transformation products:
- not measured
Applicant's summary and conclusion
- Executive summary:
On the basis of the structural similarity of the test substance ZK 137314 with ZK 90346
hydrolytic stability is to be expected at pH 7. Below and above pH 7 hydrolytic degradation will
occur.
The rate of hydrolysis of ZK 90346 was determined at pH 4, 7 and 9 (see Schering report
No. A11337). The half-lives of ZK 90346 at 25 °C are: pH 4: 17 d, pH 7: stable, pH 9: 1.2 a.
Similar rates of hydrolysis are to be expected for the test substance at pH 4 and 7. Due to the
bromine atom present in ZK 137314, the test substance may be more instable in the alkaline pH
region. However, the rate of hydrolysis of ZK 137314 cannot be experimentally determined
because the test substance is insoluble in water. The water solubility at 25 to 30 °C was
determined to be smaller than 1.5 E-03 g/L (see Schering report A01788).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
