Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 403-700-8 | CAS number: 2687-94-7 NOP; SURFADONE LP-100 SURFACTANT
Endpoint summary
Administrative data
Description of key information
The oral NOEL and NOAEL are set at 52.5 mg/kg bw/day..
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 52.5 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Additional information
Three repeated dose toxicity: oral studies are provided by ECHA in the migrated NONS files, and the results are all taken into account in this summary
The worst case result, at 90 days, is seen in Repeated dose toxicity: oral.002. This study gives a NOEL and NOAEL of 52.5 mg/kg bw/day, and this is accepted as the criticial endpoint.
Justification for classification or non-classification
N-(n-octyl)-2 -pyrrolidinone has a NOEL and NOAEL of 52.5 mg/kg. The substance therefore does not meet the requirements for a classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
