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EC number: 204-984-4 | CAS number: 130-26-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Link to relevant study records
- Endpoint:
- one-generation reproductive toxicity
- Remarks:
- based on generations indicated in Effect levels (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Qualifier:
- according to guideline
- Guideline:
- other: Effects of chinoform on pre- and post-natal development of rats at a dose level of
- Principles of method if other than guideline:
- Effects of chinoform on pre- and post-natal development of rats at a dose level of
- GLP compliance:
- not specified
- Justification for study design:
- not specified
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
- Route of administration:
- oral: unspecified
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 30 day(s) pre-mating
- Remarks:
- Doses / Concentrations:
0,120, 300,and 750 mg/kg
Basis: - Control animals:
- yes
- Parental animals: Observations and examinations:
- Pregnant rats treated with 120, 300,and 750 mg chinoform /kg showed decreased body wt. gains, decreased food-intake, and decreased water-intake at the beginning of administration. The body wts. of the mother rats treated with I were lower than those of the control group after delivery
- Clinical signs:
- effects observed, treatment-related
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- Changes observed
- Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
- Description (incidence and severity):
- Changes observed
- Dose descriptor:
- LOEL
- Effect level:
- 120 other: mg/kg
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: decreased body wt. gains
- Remarks on result:
- other: not specified
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
- Dose descriptor:
- LOEL
- Generation:
- F1
- Effect level:
- 120 other: mg/kg
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: decreased body wt. gains, retardation of ossification
- Remarks on result:
- other: not specified
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
- Reproductive effects observed:
- not specified
- Conclusions:
- The LOEL (low observed effect level ) of clioquinol in rats was observed at a dose level of 120 mg/kg/d
- Executive summary:
Pregnant rats treated with 120, 300 or 750 mg chinoform/kg showed decreased body weight gains, decreased food-intake, and decreased water-intake at the beginning of administration. Body weights of the mother rats treated with chinoform were lower than those of the control group after delivery. The body weights of the fetuses from treated rats were lower than those of the fetuses of the control group. The retardation of ossification was observed in the 5th sternebra, proximal phalanx, and caudal vertebrae when chinoform was given at 300 and 750 mg/kg. The body weights of the offspring at birth were lower than those of the control. Thus we can conclude, that the maternal and developmental toxicity LOEL (lowest observed effect level) of chinoform in Pregnant rats was observed at a dose level of 120 mg/kg.
Reference
Effect on fertility: via oral route
- Endpoint conclusion:
- adverse effect observed
- 451.71 mg/kg bw/day
- Study duration:
- chronic
- Species:
- rat
- Quality of whole database:
- The data is K2 level as the data has been obtained from QSAR model considered by OECD.
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Toxicity to reproduction
The two generation reproductive toxicity LOEL (Lowest observed effect level) of clioquinol in rat was observed at a dose concentration of 451.7103 mg/kg bw/day.On the basis of this LOEL value it indicates that clioquinol does not exhibit toxic effects to rat below the above mentioned dose.
Short description of key information:
Study indicates that clioquinol does not exhibit reprotoxic effects to rat .
Justification for selection of Effect on fertility via oral route:
The two generation reproductive toxicity LOEL (Lowest observed effect level) of clioquinol in rat was observed at a dose concentration of 451.7103 mg/kg bw/day.On the basis of this LOEL value it indicates that clioquinol does not exhibit toxic effects to rat below the above mention dose.
Effects on developmental toxicity
Description of key information
Study indicates that clioquinol does not exhibit toxic developmental effects to rat.
Link to relevant study records
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Principles of method if other than guideline:
- Clioquinol toxcity by repeated administration to Neonatal Rats
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- Wistar
- Details on test animals or test system and environmental conditions:
TEST ANIMALS:
- Housing:housed together
- Diet (e.g. ad libitum):(NMF, Oriental Yeast Co., Tokyo)
- Water (e.g. ad libitum):(NMF, Oriental Yeast Co.,Tokyo)
- Acclimation period:
ENVIRONMENTAL CONDITIONS
- Temperature (°C):22-26 oC- Route of administration:
- subcutaneous
- Vehicle:
- other: 40% polysorbate 80 aqueous solu- tion
- Details on exposure:
- The same uterine rats were divided into 2 groups. One was the clioquinol-treated group, to which the clioquinol suspension was administered subcutaneously fixed dose of 150 mg/kg/d or an increasing dose of clioquinol, which was 150 mg/kg/d from 1 to 5 d, 300 mg/kg/d from 6 to 10 d and 600 mg/kg/d from 11 to 14 d of clioquinol, was given once a day for 14 d after birth.
- Details on mating procedure:
- spermatozoa were observed in the vaginal smear was designated as day 1 of pregnancy
- Duration of treatment / exposure:
- 14days
- Frequency of treatment:
- once a day
- Remarks:
- Doses / Concentrations:
0, 120, 300 or 750 mg/kg
Basis: - No. of animals per sex per dose:
- no data
- Control animals:
- other: Yes, untreated animals
- Details on study design:
- A clioquinol suspension prepared with 40/o polysorbate 80 aqueous solu- tion according to the method described previ- ously4) was administered subcutaneously in the backs of S- and R-rats once a day from 1 d after birth for 14 d. In all experiments, the dosing volume was 4.2 1/g body weight.d.The body weights of rats were measured every day before the administration.
- Maternal examinations:
- -The body weights of rats were measured every day before the administration.
-The body weight of the clioquinol-treated rats was severely sup- pressed and the body weight of surviving S-rats increased from 6.0 ::l::: 0.3 to I 1.2 ::::t::: 2.1 g in the same period
-Thus, increasing doses of clioquinol were ad-ministered in order to induce ataxia. Only one of ten R-rats developed ataxia at 11 d after administration, whereas out of eleven S-rats, one rat developed ataxia at 9 d, another at 10 d, and a third at 12 d after the administration.
-The lipid peroxide concentrations in the liver, kidney, brain, spinal cord and plasma of the clioquinol-treated rats were not significantly different from those of the untreated rats - Statistics:
- Student's t- test;p > 0.05)
- Historical control data:
- These rats were sacrificed by drawing blood via cardiac puncture with a mi-crosyringe at 5, 10 and 15 d after the administra-tion
- Details on maternal toxic effects:
- Maternal toxic effects:yes
- Dose descriptor:
- LOEL
- Effect level:
- 300 mg/kg bw/day
- Based on:
- test mat.
- Basis for effect level:
- other: developmental toxicity
- Remarks on result:
- other: not specified
- Abnormalities:
- not specified
- Localisation:
- not specified
- Description (incidence and severity):
- not specified
- Dose descriptor:
- other: not specified
- Based on:
- not specified
- Sex:
- not specified
- Basis for effect level:
- other: not specified
- Remarks on result:
- other: not specified
- Abnormalities:
- not specified
- Localisation:
- other: not specified
- Description (incidence and severity):
- not specified
- Developmental effects observed:
- not specified
- Treatment related:
- not specified
- Conclusions:
- The developmental toxicity LOEL (lowest observed effect level ) of chinoform (Clioquinol) in Pregnant rats was observed at a dose level of 120 mg/kg.
- Executive summary:
Pregnant rats treated with 120, 300 or 750 mg chinoform/kg showed decreased body weight gains, decreased food-intake, and decreased water-intake at the beginning of administration. Body weights of the mother rats treated with chinoform were lower than those of the control group after delivery. The body weights of the fetuses from treated rats were lower than those of the fetuses of the control group. The retardation of ossification was observed in the 5th sternebra, proximal phalanx, and caudal vertebrae when chinoform was given at 300 and 750 mg/kg. The body weights of the offspring at birth were lower than those of the control.
Thus we can conclude, that the developmental toxicity LOEL (lowest observed effect level) of chinoform in Pregnant rats was observed at a dose level of 120 mg/kg.
Reference
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LOAEL
- 300 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- The data is K2 level
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
WoE Summary of 130-26-7 for developmental toxicity
Based on the various studies available with Klimish rating 2 for the target substance for CAS: 130-26-7. This data is combined with the prediction done using the QSAR toolbox for the target chemical based on similar category approach, the results is summarized as follows.
Sr. No |
End point |
Value |
Species |
Route |
Effects |
Remarks |
2 |
LOEL (Developmental toxcity) |
237 mg/Kg bw/day |
Mouse |
oral |
Reduced fetal body weights were identified at maternally toxic doses. |
Predicted data for target chemical |
|
LOEL (Developmental toxcity) |
300 mg/kg |
Rat |
subcutaneous |
increasing level of lipid peroxide concentrations in plasma, liver, kidney, brain ,body weight |
Publication data for target Cas |
3 |
LOEL (Fetotoxcity ) |
120 mg/kg bw/d |
Rat |
Oral |
Effects on Embryo or Fetus were observed Effects on Newborn - weaning or lactation index |
Publication data for target Cas |
Based on the studies summarized in the above table with oral route it can be observed that the LOAEL values varies from 120- 300 mg/Kg bw/d.The effects observed on the higher doses was listed as follows.
· Reduced fetal body weights were identified at maternally toxic doses.
· increasing level of lipid peroxide concentrations in plasma, liver, kidney, brain ,body weight
· Effects on Embryo or Fetus were observed
· Effects on Newborn - weaning or lactation index
Thus based on above discussion it can be concluded that substance CAS: 130-26-7 is expected to show the similar toxicological effect based on the effects observed on the other category members. Since the low observed effect dose value (LOEL) is 120 mg/Kg bw/d, thus based on this value it can be concluded that substance CAS: 130-26-7 is considered to be not toxic to Developmental toxicity as well as developmental effects at above mentioned dose. Also there are no known evidence of adverse effect on reproduction to Human of CAS: 130-26-7
Justification for selection of Effect on developmental toxicity: via oral route:
The LOEL (low observed effect level ) of clioquinol in rats was observed at a dose level of 300 mg/kg/d
Justification for classification or non-classification
The chemical clioquinol does not exhibit toxicity to the reproductive system within the doses mentioned in the study end points.
Additional information
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