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Diss Factsheets
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EC number: 249-047-0 | CAS number: 28473-19-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
The soil sorption coefficient for DIDS was predicted to be 28400000 L/kg (log Koc 7.45) using the OECD QSAR Toolbox (OECD, 2012).
Key value for chemical safety assessment
- Koc at 20 °C:
- 28 400 000
Additional information
In accordance with column 2 of REACH Annex VIII, an absorption / desorption screening test (required in section 9.3.1) does not need to be conducted as DIDS and its relevant degradation products decompose rapidly (i.e. DIDS is readily biodegradable).
A QSAR analysis was, however, used to predict the soil sorption coefficient (Koc) of DIDS. EPI Suite, via the OECD QSAR Toolbox (v.3.0) (OECD, 2012), estimated a Koc of 2.84 x 107 L/kg (log Koc: 7.45) from its predicted octanol/water partition coefficient (Kow). A different method (MCI model) predicted a Koc of 3.65 x 106 L/kg (log Koc: 7.20). Neither method had a defined domain. According to the ECHA guidance, such predictive methods are useful to indicate the qualitative/quantitative adsorption coefficient, and may, in some cases, be sufficient for this endpoint (ECHA, 2012b).
Henry's law constant has been estimated using the HENRYWIN (v3.20) program from EPI Suite v4.10 (US EPA, 2011) to be 50.4 Pa-m3/mole and 34.2 Pa-m3/mole by the bond contribution and group contribution methods, respectively. As an approximation (stated within REACH guidance) if Henry's law constant is greater than 100 Pa.m3/mol, more than 50% of the substance could be lost from the water phase in 3-4 hr (ECHA, 2012d).
Relevant read-across data:
A Koc value of 5.6 x 105 (log Koc: 5.75) was estimated for DEHS (Meylan et al. 1992). A predicted log Koc of 5.8 was similarly reported (ACC, 2010).
According to a classification scheme (Swann et al. 1983), substances with Koc values above 5000 (like both DIDS and DEHS) are immobile in soil. Both substances are expected to behave similarly. This supports the use of DEHS for read-across purposes.
References
ECHA (2012d). Guidance on information requirements and chemical safety assessment. Chapter R.7b: Endpoint specific guidance. Version 1.2. November 2012. Report no.: ECHA-12-G-22-EN. Owner company: European Chemicals Agency. http://echa.europa.eu/documents/10162/13632/information_requirements_r7b_en.pdf
HSDB (2003). Hazardous Substances Data Bank. Bis(2-ethylhexyl) sebacate. Last revised 14 February 2003.
Meylan WM, Howard PH and Boethling RS (1992). Molecular topology/fragment contribution method for predicting soil sorption coefficients. Environmental Science and Technology 26, 1560-1567 (cited in HSDB, 2003).
Swann RL, Laskowski DA, McCall PJ, Vander Kuy K and Dishburger HJ (1983). A rapid method for the estimation of the environmental parameters octanol/water partition coefficient, soil sorption constant, water to air ratio, and water solubility. Residue Reviews 85, 17 -28.
US EPA (2011). US Environmental Protection Agency. Estimation Programs Interface (EPI) Suite for Microsoft Windows, v 4.10.
[LogKoc: 7.45]
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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