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EC number: 219-110-7 | CAS number: 2362-14-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Buffers:
- Buffers were prepared by placing approximately 900 mL of deionised water in a graduated cylinder with the following amounts of chemicals and then bringing the volume to 1000 mL:
pH 4.0: 10.2 g hydrogen potassium phthalate + 4.0 mL 0.1 M NaOH
pH 7.0: 6.8 g KH2PO4 + 296.5 mL 0.1 M NaOH
pH 9.0: 3.1 g boric acid + 213 mL 0.1 M NaOH
The solutions were adjusted to the exact pH by addition of 5 M NaOH. The buffer solutions were filter-sterilised before use. - Details on test conditions:
- Approximately 1.5 mg of DMBPC was added to each liter of buffer and stirred for three days. After 3 days, insoluble particles were still visible. Sixty mL of buffer solution was removed and filtered through a 0.7 micron glass fiber filter into a flask. No particles were visible in the filtrate. The 0.7 micron glass fiber filter technique was previously tested with a much more concentrated DMBPC/water slurry. HPLC analysis gave a DMBPC concentration of 1.1 mg/L, which is at the solubility of DMBPC. This indicated that there were no insoluble particles present in the filtrate.
Twenty five mL of the filtrate from the buffer solutions was dispensed into each of two 50 mL glass bottles and capped with Teflon-lined caps. All glassware and utensils used in this procedure were sterilised in an autoclave. Two samples were taken from each bottle and put into HPLC vials for immediate t=0 analysis. The bottles were taped on their sides to a rack in a shaker incubator set at 50 °C and gently agitated for five days. Samples were then removed from the bottles for immediate t=5 days analysis. - Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 345 µg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 345 µg/L
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 345 µg/L
- Number of replicates:
- 2
- Positive controls:
- not specified
- Negative controls:
- not specified
- Preliminary study:
- There was no loss of DMBPC over the 5 days at 50 °C. The slight increase in recovery of the pH 4 and pH 7 samples at day 5 is unexplained. Purity checks by examination of the UV scans through the DMBPC peaks showed no secondary peak contamination.
- Test performance:
- The UV spectrum of DMBPC, as taken from the diode array detector, showed a partial peak at 230 nm which was used for quantification. The limit of detection of DMBPC was near 8 µg/L based on a signal-to-noise ratio of approximately five.
The DMBPC calibration curve showed linear relationships with correlation coefficients not less than 0.99988, indicating acceptable method precision for the analysis of DMBPC in acetonitrile (CH3CN) solution. - Transformation products:
- not specified
- Details on hydrolysis and appearance of transformation product(s):
- Not provided.
- % Recovery:
- 100
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- other: recovery determined to be 104.1 %
- Remarks:
- (substance hydrolytically stable)
- % Recovery:
- 100
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- other: recovery determined to be 103.5 %
- Remarks:
- (substance hydrolytically stable)
- % Recovery:
- 100
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- other: recovery determined to be 100.2 %
- Remarks:
- (substance hydrolytically stable)
- Remarks on result:
- hydrolytically stable based on preliminary test
- Validity criteria fulfilled:
- yes
- Conclusions:
- DMBPC as a saturated solution in aqueous buffers at pH 4.0, 7.0 and 9.0 was found to be hydrolytically stable after 5.0 days at 50 °C.
- Executive summary:
The potential of the test material to undergo hydrolysis was investigated in accordance with the standardised guideline OECD 111 under GLP conditions.
The analytical method for determination of trace amounts of DMBPC in water was an HPLC gradient method which used a standard C18 reverse phase column, a water/acetonitrile gradient, and UV detection at 230 nm.
The hydrolysis in water was evaluated in a five day study at pH 4, 7 and 9 at 50 °C. The initial concentration of DMBPC was 345 µg/L. There was no loss of the test substance after 5 d. Therefore, no value could be determined for half-life.
DMBPC as a saturated solution in aqueous buffers at pH 4.0, 7.0 and 9.0 was found to be hydrolytically stable after 5.0 d at 50 °C. At pH 4, 7 and 9, the percent recovery values were 104.1, 103.5 and 100.2, respectively. Therefore, DMBPC is not amenable to abiotic degradation via hydrolysis (i.e., is stable in water).
Reference
Observed DMBPC Concentrations in Buffer Test Solutions.
Buffer | Day 0 DMBPC (µg/L) | % RSD | Day 5 DMBPC (µg/L) | % RSD | % Recovery |
pH 4 | 345 | 2.0 | 359 | 1.7 | 104.1 |
pH 7 | 340 | 3.1 | 352 | 2.0 | 103.5 |
pH 9 | 480 | 2.4 | 481 | 1.4 | 100.2 |
%RSD = percent relative Standard Deviation [i.e. (standard deviation/mean) x 100]
Description of key information
DMBPC is not amenable to abiotic degradation via hydrolysis (i.e., is stable in water).
Key value for chemical safety assessment
Additional information
The potential of the test material to undergo hydrolysis was investigated in accordance with the standardised guideline OECD 111 under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
The analytical method for determination of trace amounts of DMBPC in water was an HPLC gradient method which used a standard C18 reverse phase column, a water/acetonitrile gradient, and UV detection at 230 nm.
The hydrolysis in water was evaluated in a five day study at pH 4, 7 and 9 at 50 °C. The initial concentration of DMBPC was 345 µg/L. There was no loss of the test substance after 5 d. Therefore, no value could be determined for half-life.
DMBPC as a saturated solution in aqueous buffers at pH 4.0, 7.0 and 9.0 was found to be hydrolytically stable after 5.0 d at 50 °C. At pH 4, 7 and 9, the percent recovery values were 104.1, 103.5 and 100.2, respectively. Therefore, DMBPC is not amenable to abiotic degradation via hydrolysis (i.e., is stable in water).
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