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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 902-591-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Remarks:
- review of literature and assessment of available human, animal and alternative data
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- EU Risk Asseessment Report Methyl Acetate
- Author:
- European Commission - ECB
- Year:
- 2 003
- Bibliographic source:
- Office for Official Publications of the European Communities, Luxemburg
Materials and methods
- Principles of method if other than guideline:
- review of literature and assessment of available human, animal and alternative data
- GLP compliance:
- not specified
- Type of study:
- other: review of literature and assessment of available human, animal and alternative data
- Justification for non-LLNA method:
- Study performed in 2003; when LLNA has not been an accepted OECD test method.
Test material
- Reference substance name:
- Methyl acetate
- EC Number:
- 201-185-2
- EC Name:
- Methyl acetate
- Cas Number:
- 79-20-9
- Molecular formula:
- C3H6O2
- IUPAC Name:
- Methyl acetate
Constituent 1
In vivo test system
Test animals
- Species:
- other: human volunteers
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Reading:
- other: Not applicable as summary of several individual studies
- Hours after challenge:
- 0
- Group:
- test chemical
- Dose level:
- Not applicable as summary of several individual studies
- No. with + reactions:
- 0
- Total no. in group:
- 25
- Clinical observations:
- No senstisation observed in studies. No sensitizing properties from experience
- Remarks on result:
- other: Summary of several individual studies
- Key result
- Reading:
- other: long experience with human exposure to the substance
- Hours after challenge:
- 0
- Group:
- negative control
- Dose level:
- No negative control tested
- No. with + reactions:
- 0
- Total no. in group:
- 0
- Clinical observations:
- Not measured/tested
- Remarks on result:
- not measured/tested
- Remarks:
- No negative control exists due to a maximisation test with 25 volunteers long experience with human exposure to the substance
- Key result
- Reading:
- other: long experience with human exposure to the substance
- Hours after challenge:
- 0
- Group:
- positive control
- Dose level:
- No positive control tested
- No. with + reactions:
- 0
- Total no. in group:
- 0
- Clinical observations:
- Not measured/tested
- Remarks on result:
- not measured/tested
- Remarks:
- No positive control exists due to a maximisation test with 25 volunteers and a long experience with human exposure to the substance.
Any other information on results incl. tables
"Total no. in group" refers to study by Kligman, only. This study is citied in EU-RAR, 2003.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Taking into account the long experience with human exposure to the substance, and the absence of any reports on contact allergy in exposed persons, methyl acetate is not expected to exhibit skin sensitizing properties, especially since the substance is hydrolysed in contact with water by non-specific tissue esterases to methanol and acetic acid. For these substances a skin sensitisation potential is either absent (methanol, Fisher, 1986) or restricted to a few cases (acetic acid, Weil and Rogers, 1951).
- Executive summary:
The result meets the long experience from human exposure to humans.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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