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EC number: 205-124-0 | CAS number: 133-91-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance 3,5-diiodosalicylic acid was found to be non toxic by any of the following route.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- mouse
- Strain:
- other: ICR;B6C3F1;ddY;no data;Swiss
- Sex:
- not specified
- Route of administration:
- other: oral: gavage;oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 410.333 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The Acute oral toxicity (LD50) value of 3,5-diiodosalicylic acid on Rat on the basis of mortality effect was estimated to be 2410.33 mg/kg bw. This value indicates that the substance 3,5-diiodosalicylic acid is not toxic to Rat by oral route.
- Executive summary:
The Acute oral toxicity (LD50) value of 3,5-diiodosalicylic acid on Rat on the basis of mortality effect was estimated to be 2410.33 mg/kg bw. This value indicates that the substance 3,5-diiodosalicylic acid is not toxic to Rat by oral route.
Reference
The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Takes average value from the 6 nearest neighbours
Domain logical expression:Result: In Domain
(("a" and ("b" and ( not "c") ) ) and ("d" and "e" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as Phenols (Acute toxicity) by US-EPA New Chemical Categories
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as Group 14 - Carbon C AND Group 16 - Oxygen O AND Group 17 - Halogens F,Cl,Br,I,At AND Group 17 - Halogens I by Chemical elements
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as Group 15 - Nitrogen N OR Group 17 - Halogens Br OR Group 17 - Halogens Cl by Chemical elements
Domain logical expression index: "d"
Parametric boundary:The target chemical should have a value of log Kow which is >= 1.33
Domain logical expression index: "e"
Parametric boundary:The target chemical should have a value of log Kow which is <= 5.03
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 410.33 mg/kg bw
- Quality of whole database:
- The data is predicted for QSAR toolbox 3.1. Based upon this available data it is expected that the test chemical 3,5-diiodosalicylic acid does not exhibit acute oral toxicity to rat within the mentioned dose level.
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Acute Toxicity -Oral:
The data has been obtained from the prediction done in QSAR 3.1 & other study from the reliable sources.
The summary of the results are presented below:
Sr. No |
Endpoint |
Species |
Route |
Effect Level |
Sources |
1 |
LD50 |
Rat |
oral: gavage |
2410.33 mg/kg bw |
QSAR Prediction |
2 |
LD50 |
Rattus norvegicus |
oral: unspecified |
2894.22mg/kg bw |
QSAR Prediction |
3 |
LD50 |
Rat |
oral: gavage |
3581.4934 mg/kg bw |
QSAR Prediction |
4 |
LDLo |
Rat |
oral: unspecified |
500 mg/kg |
Chemical-Biological Coordination Center, |
5 |
LD50 |
Mouse |
oral: unspecified |
450 mg/kg bw |
Quarterly Journal of Pharmacy & Pharmacology |
By viewing the above values the endpoint value was found to be median Lethal Dose (LD50) ranges from 3581.4934 to 500 mg/kg bw.
According to new CLP regulation, these values indicates that the substance3,5-diiodosalicylic acid is non toxic via oral route
Justification for selection of acute toxicity – oral endpoint
The predicted acute oral lethal dose (LD50) of 3,5-diiodosalicylic acid in rat was 2410.33 mg/kg of body weight. Acute toxicity of 3,5-diiodosalicylic acid to rat by oral gavage route indicates that 3,5-diiodosalicylic acid does not exhibits acute toxicity by the oral route within the dose level mentioned in the study.
Justification for classification or non-classification
Based upon the study results and available information, the substance3,5-diiodosalicylic acid is not expected to show acute toxicity effect by the oral route.
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