Registration Dossier
Registration Dossier
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EC number: 601-621-5 | CAS number: 119532-26-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- In silico prediction.
Tox Boxes 2.9 is the in house software for the prediction of basic toxicity endpoints in chemicals. Predictions are made analyzing the chemical structure and based upon large validated databases and QSAR models, in combination with expert knowledge of organic chemistry and toxicology. - GLP compliance:
- not specified
- Test type:
- other: In silico prediction
Test material
- Reference substance name:
- 1-(2,3-dichlorophenyl)piperazine hydrochloride
- EC Number:
- 601-621-5
- Cas Number:
- 119532-26-2
- Molecular formula:
- C10H13Cl3N2
- IUPAC Name:
- 1-(2,3-dichlorophenyl)piperazine hydrochloride
Constituent 1
Test animals
- Species:
- other: mouse and rats
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 440 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other: on rat
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 190 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other: on mouse
Any other information on results incl. tables
Acute toxicity shows values with moderate reliability index.
Applicant's summary and conclusion
- Interpretation of results:
- other: alert
- Remarks:
- Criteria used for interpretation of results: expert judgment
- Conclusions:
- Acute toxicity shows values with borderline and moderate reliability index.
DL50 oral rat = 440 mg/kg
DL50 oral mouse = 190 mg/kg
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