Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 605-444-4 | CAS number: 166524-64-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in accordance with generally accepted scientific principles; however full data on methodology is not given and no information relating to GLP status is provided. An accurate assessment of the study is therefore not considered to be possible.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 5-fluoro-4-hydrazinyl-2-methoxypyrimidine
- EC Number:
- 605-444-4
- Cas Number:
- 166524-64-7
- Molecular formula:
- C5H7FN4O
- IUPAC Name:
- 5-fluoro-4-hydrazinyl-2-methoxypyrimidine
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): 5-fluoro-4-hydrazino-2-methoxypyrimidine- Physical state: solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Weight at study initiation: 155.4 - 252.6 gNo further information is provided on test animals and environmental conditions.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Test material was administered as a 1, 10 or 20 % suspension in water by single dose oral gavage.
- Doses:
- 50, 100, 500, 1000 or 2000 mg/kg
- No. of animals per sex per dose:
- 3 males per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days- Frequency of weighing: surviving animals were weighed on test days 1, 2, 8 and 15- Necropsy of survivors performed: no data- Other examinations performed: clinical observations were recorded during the 14 day observation period
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 100 - 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals dosed at 500 mg/kg and above died on the day of dosing while all animals dosed at 50 or 100 mg/kg survived the 14 day observation period.
- Clinical signs:
- other: Clinical observations in animals dosed at 2000 mg/kg consisted of convulsions and tremors. Clinical observations in animals dosed at 1000 mg/kg consisted of salivation, incoordination and convulsions. Clinical observations in animals dosed at 500 mg/kg co
Any other information on results incl. tables
Table 1: Individual Body Weights (grams)
Dose (mg/kg) | Test day | |||
1 | 2 | 8 | 15 | |
50 | 160.8 | 180.3 | 207.8 | 233.7 |
162.2 | 183.5 | 204.7 | 214.8 | |
169.0 | 185.6 | 211.0 | 230.8 | |
100 | 166.5 | 185.5 | 213.0 | 236.8 |
162.9 | 180.7 | 197.1 | 213.0 | |
160.4 | 181.4 | 198.3 | 214.4 | |
500 | 163.3 | *** | *** | *** |
157.7 | *** | *** | *** | |
159.3 | *** | *** | *** | |
1000 | 159.3 | *** | *** | *** |
155.4 | *** | *** | *** | |
160.8 | *** | *** | *** | |
2000 | 252.6 | *** | *** | *** |
245.8 | *** | *** | *** | |
198.5 | *** | *** | *** |
*** No data, dead animal
Applicant's summary and conclusion
- Interpretation of results:
- other: Category 3
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 for male Fischer 344 rats was estimated to be between 100 and 500 mg/kg. It is therefore considered that the test material requires classification as Category 3 for acute oral toxicity in accordance with EU CLP criteria.
- Executive summary:
The acute oral toxicity of the test material was investigated in a study which was conducted to a method similar to that which is outlined in standardised guideline OECD 401.
During the study, groups of 3 male rats each received 50, 100, 500, 1000 or 2000 mg/kg test material, as a 1, 10 or 20 % suspension in water, by single oral gavage. Clinical observations and body weight measurements were recorded during the 14 day observation period.
All animals dosed at 500 mg/kg and above died on the day of dosing while all animals dosed at 50 or 100 mg/kg survived the 14 day observation period.
Clinical observations in animals dosed at 2000 mg/kg consisted of convulsions and tremors. Clinical observations in animals dosed at 1000 mg/kg consisted of salivation, incoordination and convulsions. Clinical observations in animals dosed at 500 mg/kg consisted of salivation, incoordination, blood on the muzzle and convulsions. There were no significant clinical observations recorded in animals dosed at 50 or 100 mg/kg.
All surviving animals gained weight by the end of the 14 day observation period.
Under the conditions of this study, the acute oral LD50 for male Fischer 344 rats was estimated to be between 100 and 500 mg/kg. It is therefore considered that the test material requires classification as Category 3 for acute oral toxicity in accordance with EU criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.