Registration Dossier
Registration Dossier
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EC number: 204-557-2 | CAS number: 122-60-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with restrictions (limited documentation, occlusive dressing)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List V
- Author:
- Smyth HF, Carpenter CP, Weil CS, Pozzani UC
- Year:
- 1 954
- Bibliographic source:
- Arch. Ind. Hyg. Occupational Med. 10, 61-68
- Reference Type:
- secondary source
- Title:
- Experimental Carcinogenicity and Acute Toxicity of Representative Epoxides
- Author:
- Weil CS, Condra N, Haun C, Striegel JA
- Year:
- 1 963
- Bibliographic source:
- Industrial Hygiene Journal, 305-325
- Reference Type:
- secondary source
- Title:
- Epoxy Compounds
- Author:
- Waechter JM et al.
- Year:
- 2 001
- Bibliographic source:
- Patty´s Toxicology, fifth edition, vol. 6, 1063-1085
- Reference Type:
- secondary source
- Title:
- IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
- Author:
- WHO IARC
- Year:
- 1 989
- Bibliographic source:
- IARC Monographs, Volume 47, 237-261
- Reference Type:
- secondary source
- Title:
- Phenyl glycidyl ether
- Author:
- MAK Commission
- Year:
- 1 991
- Bibliographic source:
- MAK List 1991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- limited documentation, occlusive dressing
- Test type:
- standard acute method
Test material
- Reference substance name:
- phenyl glycidyl ether
- IUPAC Name:
- phenyl glycidyl ether
- Details on test material:
- - Name of test material (as cited in study report): phenyl glycidyl ether
No further information.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 to 3.5 kg
No further information.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
- Area of exposure: entire trunk
- % coverage: 1/10 of the body surface
- Type of wrap if used: impervious plastic film (Cuff method of Draize).
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): not more than 20 ml/kg bw. - Duration of exposure:
- 24 hours
- Doses:
- No data.
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- No data.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 666 mg/kg bw
- 95% CL:
- 1 070 - 2 100
- Remarks on result:
- other: calculated on a density of 1.1109 kg/l (a value of 1.5 ml/kg bw was given in the raw data)
- Mortality:
- No data.
- Clinical signs:
- other: No data.
- Gross pathology:
- No data.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
