Registration Dossier
Registration Dossier
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EC number: 203-176-9 | CAS number: 104-12-1
Endpoint summary
Administrative data
Description of key information
acute oral toxicity: LD50 = 138 mg/kg bw (rat, female); LD50 = 335 mg/kg bw (rat, male); other studies found a LD50 > 2000 mg/kg bw (rat, male); LD50 = 6000 mg/kg bw (rat, m+f) or LD50 = 4750 mg/kg bw (rat, m+f)
acute inhalation toxicity: LC50 = ca.113 mg/m³ (rat, female); LC50 = 113-272 mg/m³(rat, male)
acute dermal toxicity: LD50 > 2000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 138 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 113 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Justification for classification or non-classification
For the acute oral toxicity T, R25 is justified as a result of the LD50 = 138 mg/kg bw
For the acute inhalation toxicity T+, R26 is justified as a result of the LC50 = 113 mg/m³ air
In addition, several studies reported respiration irritational effects. Therefore R 37 is applicable
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