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EC number: 203-500-9 | CAS number: 107-54-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Primary Skin Irritation Score: 1.5
The subject material is a primary ocular irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Methyl pentynol is a structural analogon to the to be registered substance. Justification for read across is perfectly provided in the document "Screening-Level Hazard Characterization and Prioritization Document on ALPHA HYDROXY ALKYNES CLUSTER - 4 Chemicals" prepared by EPA in 2009. This document is attached at this endpoint of this dossier.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Section 1500.41, - Hazardous Substances and Articles, Administration and Enforcement Regulations, Federal Register, Vol. 38, No. 187, P. 27019, 27 September 1973.
- Deviations:
- not specified
- Principles of method if other than guideline:
- In carrying out the study the experimental sample was used as supplied. A group o f six albino rabbits were clipped over a wide area. One side o f the animals' backs was abraded at one site with a lancet sufficiently deep to penetrate the stratum corneum but not enter the derma to produce bleeding.
The skin of the other side was allowed to remain intact. A 0.5 ml portion of material was applied to an abraded and an intact skin site on the same rabbit.
Gauze patches were then placed over the treated areas and an impervious material was wrapped snugly around the trunks of the animals to hold the patches in place.
The wrapping was removed at the end o f the twenty-four hour period and the treated areas were examined. Readings were also made after seventy-two hours. The Draize method of scoring was employed. - GLP compliance:
- no
- Species:
- rabbit
- Strain:
- other: albino
- Type of coverage:
- semiocclusive
- Preparation of test site:
- abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours
- Number of animals:
- 6 rabbits
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Section 1500.41, - Hazardous Substances and Articles, Administration and Enforcement Regulations, Federal Register, Vol. 38, No. 187, P. 27019, 27 September 1973.
- Conclusions:
- Based on the accompanying table, the subject material would not be classified as a primary irritant to albino rabbits within the definition of the Act-Reference: Section 1500.3 (c) (4) and requires no cautionary labeling with respect to that section.
Primary Irritation Score:
6.0 / 4 = 1.5 - Executive summary:
Based on the accompanying table, the subject material would not be classified as a primary irritant to albino rabbits within the definition of the Act-Reference: Section 1500.3 (c) (4) and requires no cautionary labeling with respect to that section.
Primary Irritation Score:
6.0 / 4 = 1.5
Reference
Reading (Hours) | Rabbit Number | |||||||||
Erythema and Eschar Formation | 1 | 2 | 3 | 4 | 5 | 6 | Average | |||
Intact Skin | 24 | 1 | 1 | 1 | 1 | 1 | 1 | 1.0 | ||
Intact Skin | 72 | 1 | 1 | 1 | 1 | 1 | 1 | 1.0 | ||
Abraded Skin | 24 | 1 | 1 | 1 | 1 | 1 | 1 | 1.0 | ||
Abraded Skin | 72 | 1 | 1 | 1 | 1 | 1 | 1 | 1.0 | ||
Subtotal | 4.0 | |||||||||
Reading (Hours) | Rabbit Number | |||||||||
Edema Formation | 1 | 2 | 3 | 4 | 5 | 6 | Average | |||
Intact Skin | 24 | 1 | 1 | 1 | 1 | 1 | 1 | 1.0 | ||
Intact Skin | 72 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | ||
Abraded Skin | 24 | 1 | 1 | 1 | 1 | 1 | 1 | 1.0 | ||
Abraded Skin | 72 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | ||
Subtotal | 2.0 | |||||||||
Total | 6.0 | |||||||||
Primary Irritation Score:
6.0 / 4 = 1.5
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Methyl pentynol is a structural analogon to the to be registered substance. Justification for read across is perfectly provided in the document "Screening-Level Hazard Characterization and Prioritization Document on ALPHA HYDROXY ALKYNES CLUSTER - 4 Chemicals" prepared by EPA in 2009. This document is attached at this endpoint of this dossier.
- Qualifier:
- according to guideline
- Guideline:
- other: Section 1500.42 - Hazardous Substances and Articles, Administration and Enforcement Regulations, Federal Register, Vol . 38, No. 187, P. 27019, 27 September 1973
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- other: albino
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 ml
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6 animals
- Interpretation of results:
- other: primary ocular irritant
- Remarks:
- Criteria used for interpretation of results: other: Section 1500.42 (b) (1) (2) P. 27019 - "Illustrated Guide for Grading Eye Irritation By Hazardous Substances"
- Conclusions:
- The subject material is a primary ocular irritant within the definition of the Act-Reference:
Section 1500.42 (b) (1) (2) P. 27019 and requires cautionary labeling with respect to that section. - Executive summary:
The subject material is a primary ocular irritant within the definition of the Act-Reference:
Section 1500.42 (b) (1) (2) P. 27019 and requires cautionary labeling with respect to that section.
Reference
Hours After Application | Days After Application | ||||||||||||||||||
1 | 24 | 72 | 5 | 7 | |||||||||||||||
Rabbit Number | Cornea | Iris | Conjunctivae | Cornea | Iris | Conjunctivae | Cornea | Iris | Conjunctivae | Cornea | Iris | Conjunctivae | Cornea | Iris | Conjunctivae | Cornea | Iris | Conjunctivae | |
1 | 40 | 10 | 20 | 40 | 10 | 20 | 40 | 10 | 20 | 40 | 10 | 20 | 40 | 10 | 20 | 40 | 10 | 16 | |
2 | 40 | 10 | 20 | 40 | 10 | 20 | 40 | 10 | 16 | 40 | 10 | 16 | 40 | 10 | 14 | 40 | 10 | 12 | |
3 | 40 | 10 | 20 | 40 | 10 | 20 | 40 | 10 | 20 | 40 | 10 | 20 | 40 | 10 | 20 | 40 | 10 | 18 | |
4 | 40 | 10 | 20 | 40 | 10 | 20 | 40 | 10 | 12 | 40 | 10 | 12 | 40 | 10 | 10 | 40 | 10 | 10 | |
5 | 40 | 10 | 20 | 40 | 10 | 20 | 40 | 10 | 20 | 40 | 10 | 20 | 40 | 10 | 20 | 40 | 10 | 20 | |
6 | 40 | 10 | 20 | 40 | 10 | 20 | 40 | 10 | 18 | 40 | 10 | 16 | 40 | 10 | 16 | 40 | 10 | 16 | |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No study availabe on the substance as such, but a study on a surrogate is available: Methyl pentynol is a structural analogon to the to be registered substance. Justification for read across is perfectly provided in the document "Screening-Level Hazard Characterization and Prioritization Document on ALPHA HYDROXY ALKYNES CLUSTER - 4 Chemicals" prepared by EPA in 2009. This document is attached at the corresponding endpoint of this dossier.
Justification for selection of eye irritation endpoint:
No study availabe on the substance as such, but a study on a surrogate is available: Methyl pentynol is a structural analogon to the to be registered substance. Justification for read across is perfectly provided in the document "Screening-Level Hazard Characterization and Prioritization Document on ALPHA HYDROXY ALKYNES CLUSTER - 4 Chemicals" prepared by EPA in 2009. This document is attached at the corresponding endpoint of this dossier.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: highly irritating
Justification for classification or non-classification
According to the UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Part 3 Chapter 3.2 and Chapter 3.3 it is classified to be (severe) irritating to eye and (mild) skin irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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