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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Three valid studies for skin irritation/corrosion and two valid studies for eye irritation are available.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Principles of method if other than guideline:
A dose of 500 mg/animal of chinizarin roh was applied to the inner surface of one ear each on 2 rabbits; exposure time was 24 hours. The test-substance was fixed by a plaster. After the exposition the test substance was removed with water and soap/plantoil. The post exposure observation time was 7 days.
GLP compliance:
not specified
Species:
rabbit
Strain:
New Zealand White
Type of coverage:
semiocclusive
Preparation of test site:
not specified
Controls:
not required
Duration of treatment / exposure:
24 hours
Observation period:
7 days
Number of animals:
2 animals
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 0 h, 48 h, and 7 d
Score:
0
Max. score:
4
Reversibility:
other: not applicable - score = 0 at any time point
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 0 h, 48 h, and 7 d
Score:
0
Max. score:
4
Reversibility:
other: not applicable - score = 0 at any time point
Irritant / corrosive response data:
Chinizarin roh is not irritating to the skin (score = 0 at any time point).
Other effects:
No data.

No data.

Interpretation of results:
GHS criteria not met
Conclusions:
Chinizarin roh is not irritating to the skin (score = 0 at any time point). According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification is therefore not justified.
Executive summary:

A dose of 500 mg/animal of chinizarin roh was applied to the inner surface of one ear each on 2 rabbits; exposure time was 24 hours. The test-substance was fixed by a plaster. After the exposition the test substance was removed with water and soap/plantoil. The post exposure observation time was 7 days.

Chinizarin roh is not irritating to the skin (score = 0 at any time point).

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Principles of method if other than guideline:
50 mg test substance was applied into the conjuctival sac of 2 rabbits. Post exposure time was 7 days. Eyes were examinated after application of test substance up to 7 days
GLP compliance:
not specified
Species:
rabbit
Strain:
New Zealand White
Vehicle:
unchanged (no vehicle)
Controls:
not required
Duration of treatment / exposure:
7 days
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
2 animals
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 24, 48 and 72 h
Score:
0
Max. score:
4
Reversibility:
other: not applicable - score = 0 at any time point
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 24, 48 and 72 h
Score:
0
Max. score:
2
Reversibility:
other:
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24, 48 and 72 h
Score:
0
Max. score:
3
Reversibility:
other:
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 24, 48 and 72 h
Score:
0
Max. score:
4
Reversibility:
other:
Irritant / corrosive response data:
Chinizarin roh is not irritating to the eyes (cornea score, iris score, conjunctivae score and chemosis score = 0 at 24, 48 and 72 hours).
Other effects:
No data

No data.

Interpretation of results:
GHS criteria not met
Conclusions:
Chinizarin roh is not irritating to the eyes (cornea score, iris score, conjunctivae score and chemosis score = 0 at 24, 48 and 72 hours). According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification is therefore not justified.
Executive summary:

50 mg test substance was applied into the conjuctival sac of 2 rabbits. Post exposure time was 7 days. Eyes were examinated after application of test substance up to 7 days.

Chinizarin roh is not irritating to the eyes (cornea score, iris score, conjunctivae score and chemosis score = 0 at 24, 48 and 72 hours).

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

In all available studies for skin irritation/corrosion and eye irritation, the test substance (1,4-dihydroxyanthraquinone) was negative.

Justification for classification or non-classification

In all available studies for skin irritation/corrosion and eye irritation, the test substance (1,4-dihydroxyanthraquinone) was negative.

According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification is therefore not justified.