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EC number: 412-280-5 | CAS number: 2511-00-4 POIRENATE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 4 to 18 November 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: it is GLP and according EU method B.3
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Ethyl 2-cyclohexylpropionate
- EC Number:
- 412-280-5
- EC Name:
- Ethyl 2-cyclohexylpropionate
- Cas Number:
- 2511-00-4
- Molecular formula:
- C11H20O2
- IUPAC Name:
- ethyl 2-cyclohexylpropanoate
- Details on test material:
- - Physical state: clear liquid
- Storage condition of test material: 4ºC im the dark
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River U.K Limited, Margate, Kent, England
- Age at study initiation: 7-10 weeks
- Weight at study initiation: 212-235 g
- Fasting period before study:
- Housing: individually in metal cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-22ºC
- Humidity (%): 59
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light):12/12
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The test substance was applied by spreading it evently over the prepared skin. The treated are (approximately 50 mm x 50 mm) was then promptly covered with gauze which was held in place with an impermeable dressing encircled firmly around the trunk.
At the end of the 24-hour exposure period, the dressing were carefully removed and the treated area of skin was washed with in warm (30º to 40ºC) water and blotted dry with absorbent paper. - Duration of exposure:
- 24 h
- Doses:
- 2.09 ml/kg
- No. of animals per sex per dose:
- A group of ten rats (five males and five females) was treated at 2.0 g/kg bodyweight.
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no deaths following a single dermal application of the test substance at 2.0 g/kg bodyweight.
- Clinical signs:
- other: There were no signs of systemic reaction to treatment
- Gross pathology:
- MACROSCOPIC EXAMINATION
No macroscopic abnormalities were observed for animals killed on Day 15. - Other findings:
- DERMAL RESPONSES
Sites of application of the test substance showed no irritation or other dermal changes (score of zero for erythema and oedema were recorded for all animals)
Any other information on results incl. tables
TABLE 1
Individual bodyweights (g) of rats dosed dermally with the test substance
Sex | Dose | Animal number & ear mark | Bodyweight (g) at | ||
Day 1 | Day 8 | Day 15 | |||
Male | 2 | 1 RP | 225 | 280 | 328 |
2 LP | 232 | 286 | 344 | ||
3 RPLP | 224 | 281 | 345 | ||
4 RIRO | 233 | 290 | 339 | ||
5 LILO | 235 | 281 | 337 | ||
Female | 2 | 6 RP | 212 | 247 | 277 |
7 LP | 217 | 250 | 274 | ||
8 RPLP | 213 | 226 | 250 | ||
9 RIRO | 218 | 246 | 271 | ||
10 LILO | 224 | 239 | 260 |
TABLE 2
Indivual bodyweight changes (g) of rats dosed dermally with the test substance
Sex | Dose | Animal number & ear mark | Bodyweight gains (g) at | |
Day 1 | Day 8 | |||
Male | 2 | 1 RP | 55 | 48 |
2 LP | 54 | 58 | ||
3 RPLP | 57 | 64 | ||
4 RIRO | 57 | 49 | ||
5 LILO | 46 | 56 | ||
Female | 2 | 6 RP | 35 | 30 |
7 LP | 33 | 24 | ||
8 RPLP | 13 | 24 | ||
9 RIRO | 28 | 25 | ||
10 LILO | 15 | 21 |
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute lethal dermal dose to rats of the tests subatcne was found to be greater than 2.0 g/kg bodyweight
- Executive summary:
A study performed to assess the acute dermal toxicity of the test substance tot he rat. The method followed was that described in EEC Methods for the determination of toxicity, Directive 84/449/EEC, Part B, Method B.3. Acute toxicity dermal.
A group of ten rats (five males and five females) was given in a single dermal application of the test substance, as supplied, at a dose level of 2.0 g/kg bodyweight. All animals were killed and examined macroscopically on Day 15, the end of the observation period.
/There were no deaths and no signs of systemic reactions to treatment.
Site of application of the test substance showed no irritation or other dermal changes.
A slightly low bodyweight gain was recorded for one male on Day 8; this rat achieved an anticipated gain on Day 15. All other rats achieved anticipated bodyweight gains throughout the study.
No obnormalities were recorded at the macroscopic examination on Day 15.
The acute lethal dermal dose to rats of the test substance was found to be greater than 2.0 g/kg bodyweight.
The test substance not require labelling with the risk phrase R "Harmful in contact with skin", in accordance with Council Directive 79/831/EEC Annex VI, Part II (D) as described in Comission Directive 91/325/EEC.
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