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EC number: 456-880-5 | CAS number: 439685-79-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Absorption of Mexoryl SBF by oral route is likely to be limited while Mexoryl SBF as not volatil hydrophilic paste is unlikely to be absorbed at significant rate by dermal route or by inhalation.
If absorbed, Mexoryl SBF may be transported through the circulatory system but distribution into fatty tissues should be low. Moreover, Mexoryl SBF is expected to be mainly excreted in urine if absorbed.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
There is no specific requirement to generate toxicokinetic information in REACH. However, some indications regarding the toxicokinetic profile of Mexoryl SBF (i.e.absorption, distribution, metabolism and elimination) was derived from the physical chemical characteristics of the substance.
Physico-chemical characteristics
Mexoryl SBF is a multi-constituent substance composed of two consituents having a relatively low molecular weight of 192 g/mol. The substance is highly water soluble (> 590 g/L), hydrophilic based on the octanol/water partition coefficient (log Kow = -2.07,) and not volatile according to its vapour pressure (1.7x10-6Pa at 25°C). The hydrolysis study concluded that Mexoryl SBF is considered as hydrolytically stable at pH 4, pH 7 and pH 9, with half-life at 25°C considered to be greater than 1 year.
Absorption
The physical chemical characteristics described above suggest that Mexoryl SBF is of adequate molecular size to participate in endogenous absorption mechanisms within the mammalian gastrointestinal tract. However, being hydrophilic, crossing of gastrointestinal epithelial barriers by Mexoryl SBF is likely to be limited even if the absorption may be promoted by the ability of the substance to dissolve into gastro-intestinal fluids and hence make contact with the mucosal surface.
Regarding the dermal absorption, Mexoryl SBF being hydrophilic paste (log Kow = -2.07), the rate of uptake into the stratum corneum is expected to be very low even nonexistent. Moreover, enhanced skin penetration is not expected since Mexoryl SBF is not a skin irritant or corrosive even after repeated (14 days) dermal application (see section 7.5.3).
The potential for inhalation toxicity was not evaluated in vivo. However, the vapour pressure of Mexoryl SBF (1.7x10-6Pa at 25°C) indicated an absence of volatility and therefore no exposure by inhalation is anticipated. Thus, at ambient temperature, no respiratory absorption is expected under normal use and handling of the paste which is Mexoryl SBF.
Distribution
Systemic distribution of Mexoryl SBFcan be predicted from its physical chemical characteristics. Considering that the substance is hydrophilic (log Pow = -2.07) and highly water soluble, it is suggested that, upon systemic absorption, Mexoryl SBF may be transported through the circulatory system in association with a carrier molecule such as a lipoprotein or other macromolecule. However based on its very low lipophilic character, the substance won’t cross cellular barriers easily and therefore distribution into fatty tissues should be low.
Metabolism
Excretion
Having a molecular weight lower than 300, Mexoryl SBF is expected to be mainly excreted in urine if it is absorbed.
Following dermal exposure, hydrophilic substances, such as Mexoryl SBF, that have penetrated the stratum corneum at slow and low rate may be sloughed off with skin cells during the natural desquamation process.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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