Registration Dossier
Registration Dossier
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EC number: 233-153-9 | CAS number: 10045-95-1
Endpoint summary
Administrative data
Description of key information
Acute toxicity: oral:
A K2 acute oral toxicity test was performed in female Sprague-Dawley rats according to a guideline similar to OECD Guideline 401 (Bruce DW, 1963). This study was selected as key study since this is the only available reliable study (K2).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 750 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute toxicity: oral
Bruce DW (1963) investigated the acute oral toxicity via gavage of a single oral dose of neodymium nitrate in 5 to 10 female Sprague-Dawley rats. The animals were observed for 30 days although no deaths occurred later than 4 days after administration. Within 1 to 2 hours after oral administration of the rare earth nitrate most of the rats were depressed, and animals that received lethal doses showed little activity during the survival period. Throughout the observation period no gross pathologic changes were noted. The acute oral LD50 of neodymium nitrate in female rats was determined to be 2750 mg/kg. This study is considered key study.
Another publication was identified (Lewis 1995) but it is a secondary source of Bruce (1963). Therefore it is scored as K4.
No data were available for the inhalation and dermal route.
Justification for selection of acute toxicity – oral endpoint
Only K2 available. No classification needed on the basis of the effect level.
Justification for classification or non-classification
Based on the results of the acute oral toxicity study and according to the criteria of the DSD and CLP Regulation, neodymium trinitrate should not be classified as an acute oral toxicant.
No data were available to decide on the classification for the inhalation and dermal route.
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